implant with bone contact elements having flat wavy and helical geometries

专利摘要:
an implant includes a first body member and a second body member connected by a plurality of bone contact elements. some of the bone contact elements may have a generally helical geometry. some of the bone contact elements may have a wavy plane geometry. the bone contact elements may have a rounded cross-sectional shape or a rectangular cross-sectional shape.
公开号:BR112019018976A2
申请号:R112019018976
申请日:2018-03-12
公开日:2020-04-28
发明作者:M. Nyahay Joseph；J. McShane Edward III；S. Bishop Sean；J. Ryan Christopher；A. Stauffer Megan
申请人:Institute for Musculoskeletal Science and Education, Ltd.；
IPC主号:

专利说明:

IMPLANT WITH BONE CONTACT ELEMENTS HAVING CORRUGATED AND HELICIDE FLAT GEOMETRIES
BACKGROUND [001] The modalities are generally aimed at implants to support bone growth in a patient.
[002] A variety of different implants are used in the body. The implants used in the body to stabilize an area and promote bone growth provide stability (that is, minimal deformation under pressure over time) and space for bone growth.
[003] Spinal fusion, also known as spondylodesis or spondylosindesis, is a surgical treatment method used to treat various morbidities such as degenerative disc disease, spondylolisthesis (slipping of a vertebra), spinal stenosis, scoliosis, fracture, infection or tumor. The purpose of the spinal fusion procedure is to reduce instability and therefore pain.
[004] In preparation for spinal fusion, most of the intervertebral disc is removed. An implant, the spinal fusion box, can be placed between the vertebra to maintain the alignment of the spine and the height of the disc. The fusion, that is, bone bridge, occurs between the end plates of the vertebrae.
SUMMARY [005] In one aspect, an implant includes a first body member and a second body member, a first bone contact element with a first side wall and a second bone contact element with a second side wall. The first bone contact element extends to
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2/51 from the first body member to the second body member and the second bone contact element extends from the first body member to the second body member. The first side wall of the first bone contact element is attached to the second side wall of the second bone contact element in a connecting portion.
[006] In another aspect, an implant includes a first body member, a second body member and a bone contact element that extends from the first body member to the second body member. The bone contact element has a flat wavy geometry.
[007] In another aspect, an implant includes an upper side, a lower side and a lateral side. The implant also includes a first body member and a second body member. The implant also includes a first bone contact element that extends from the first body member to the second body member, where the first bone contact element is disposed adjacent to a location where the lateral side meets the upper side. The implant also includes a second bone contact element that extends from the first body member to the second body member, where the second bone contact element is disposed adjacent to a location where the lateral side meets the underside. The implant also includes a support wall that extends on the side between the first bone contact element and the second bone contact element. The implant also includes a third bone contact element that intercepts the support wall.
[008] In another aspect, an implant includes a first body member and a second body member. The implant
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3/51 also includes a first direction that extends from the first body member to the second body member and a second direction perpendicular to the first direction. The implant also includes a central bone contact element that generally extends along the second direction. The central bone contact element has a wavy plane geometry.
[009] Other systems, methods, characteristics and advantages of the modalities will be or will become evident to a person with common knowledge in the technique after examining the following figures and detailed description. It is intended that all such systems, methods, characteristics and additional advantages are included in this description and in this summary, are within the scope of the modalities, and are protected by the following claims.
BRIEF DESCRIPTION OF THE DRAWINGS [0010] The modalities can be better understood with reference to the following drawings and description. The components in the figures are not necessarily to scale,
emphasizing instead of that illustration of Principles of modalities Beyond of this, in the figures, the numbers in reference designate parts corresponding over of
different views.
[0011] Figure 1 is a schematic isometric view of a step of implanting a device in a spine, according to a modality;
[0012] Figure 2 is a schematic isometric view of a device implanted inside a spine, according to a modality;
[0013] Figure 3 is a schematic isometric view of
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4/51 an embodiment of an implant;
[0014] Figure 4 is a schematic isometric view of an embodiment of an implant;
[0015] Figure 5 is a schematic isometric view of a modality of a bone contact element with a generally helical geometry;
[0016] Figure 6 is a schematic isometric view of the implant of Figure 3, in which a single bone contact element is detached;
[0017] Figure 7 is a schematic top-down view of some elements of an implant, in which two of the elements have a wavy geometry, according to a modality;
[0018] Figure 8 is a schematic top-down view of the implant of Figure 3;
[0019] Figure 9 is a schematic side view of the implant of Figure 3;
[0020] Figure 10 is a schematic view of various types of connections between bone contact elements, according to a modality;
[0021] Figure 11 is a schematic top-down view of the implant of Figure 3, in which an enlarged view of a connection region is also shown;
[0022] Figure 12 is a schematic isometric view of the implant of Figure 3, in which several connection regions are highlighted;
[0023] Figure 13 is a schematic isometric view of the Figure 3 implant, in which the relative amplitudes of three adjacent bone contact elements are compared schematically;
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5/51 [0024] Figure 14 is a schematic view of an implant with a textured surface to promote bone growth, according to one modality;
[0025] Figure 15 is an anterior view schematic of
another modality of an implant with bone contact elements;
[0026] Figure 16 is a rear view implant
Figure 15;
[0027] Figure 17 is a top view implant
Figure 15;
[0028] Figure 18 is a side view implant
Figure 15;
[0029] Figure 19 is a schematic view of an element
bone contact that intercepts a wall support
according to a modality;
[0030] Figure 20 is a top view down the
bone contact element that intercepts the support wall of Figure 19;
[0031] Figure 21 is an anterior view of another modality of an implant with elements of bone contact;
[0032] Figure 22 is a rear view implant
Figure 21;
[0033] Figure 23 is a top view implant
Figure 21;
[0034] Figure 24 is a side view implant
Figure 21;
[0035] Figure 25 is an isometric view schematic of
a bone contact element with a rectangular cross section having a wavy geometry, according to one embodiment;
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6/51 [0036] Figure 4 is an isometric view of an embodiment of an implant;
[0037] THE Figure 27 it's a sight higher of implant gives Figure 26; [0038] THE Figure 28 it's a sight side of implant gives Figure 26; [0039] THE Figure 29 is an isometric view of implant gives
Figure 26, in which some elements of bone contact have been removed for clarity;
[0040] Figure 30 is an isometric view of another modality of an implant;
[0041] Figure 31 is an isometric view of another modality of an implant;
[0042] Figure 32 is a top view of the implant of Figure 31;
[0043] Figure 33 is a side view of the implant of the
Figure 31;
[0044] THE Figure 34 is an View isometric otherwise modality of an implant;[0045] THE Figure 35 is an View higher of implant shown in Figure 34; and[0046] THE Figure 36 is an View side of implant
shown in Figure 34.
DETAILED DESCRIPTION [0047] The modalities described here are aimed at an implant for use in a spine. In addition to the various provisions discussed below, any modalities can make use of any of the body / support structures, frames, plates, coils or other structures disclosed in Morris et al., Publication number US 2016/0324656,
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7/51 published on November 10, 2016, currently US Patent Application No. 15 / 141,655, filed on April 28, 2016 and entitled Rolled Implants and Same Use Systems and Methods, which is incorporated herein by reference in its entirety. For convenience, the Morris order will be referred to throughout this order as The Rolled Implant Order. In addition, any modalities can make use of any of the body / support structures, members, elements, frames, plates or other structures disclosed in McShane III et al., Publication number US 2017/0042697, published on February 16, 2017, currently US Patent Application No. 15/334053, filed on October 25, 2016 and entitled Implant with Arched Bone Contact Elements, which is hereby incorporated by reference in its entirety. In addition, any modalities can make use of any of the body / support structures, limbs, elements, frames, plates or other structures disclosed in McShane III et al., US Publication Number ________, published on ______, currently Patent Application US No. 15/334022, filed on October 25, 2016 and entitled Implant with Protected Fusion Zones (Lawyer Document No. 138-1007), which is incorporated by reference in its entirety and referred to as Request for Protected Fusion Zones. In addition, any modalities can make use of any of the body / support structures, limbs, elements, frames, plates or other structures disclosed in US Publication Number ________, published on ______, currently US Patent Application _______, filed on 13 March 2017 and entitled Corpectomy Implant (Lawyer Document No. 138Petition 870190121222, of 11/22/2019, page 48/92
8/51
1042), which is incorporated by reference in its entirety.
[0048] Implantation [004 9] Figure 1 is a schematic view of a modality of an implant 100. For purposes of context, implant 100 is shown adjacent to a portion of a spine 101. In Figure 2, a modality of implant 100 is shown after insertion between two adjacent vertebrae (vertebra 192 and vertebra 194) within the spine 101. This insertion is facilitated by the use of an insertion tool 105, which is shown schematically in Figures 1 and 2.
[0050] For purposes of this disclosure, implant 100 may also be referred to as a box or fusion device. In some embodiments, implant 100 is configured to be implanted within a part of the human body. In some embodiments, implant 100 can be configured for implantation in the spine. In some embodiments, implant 100 may be a spinal fusion implant, or spinal fusion device, which is inserted between adjacent vertebrae to provide support and / or facilitate fusion between the vertebrae.
[0051] In some modalities, implant 100 can be inserted using a surgical procedure of anterior lumbar intercorporeal fusion (ALIF), where the disc space is fused when approaching the spine through the abdomen. In the ALIF approach, a three to five inch incision is usually made near the abdomen and the abdominal muscles are retracted to the side. In some cases, implant 100 can be inserted through a small incision in the front or the front side of the body. In some cases, an approach
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Previous 9/51 can provide better exposure to disk space for a surgeon. The previous approach may allow a larger device to be used for fusion, increasing the surface area for fusion and allowing for greater post-operative stability. An earlier approach often makes it possible to reduce some of the deformities caused by various conditions, such as isthmic spondylolisthesis. The insertion and placement of the disc along the front of a human body can also restore the patient's normal sagittal alignment in some cases, giving individuals a more normal internal curve to the lower back.
[0052] Introduction to the implant [0053] For the sake of clarity, reference is made to several directional adjectives throughout the detailed description and in the claims. As used herein, the previous term refers to a side or part of an implant that is intended to be oriented towards the front of the human body when the implant was placed in the body. Likewise, the term later refers to a side or portion of an implant that is intended to be oriented towards the back of the human body after implantation. In addition, the upper term refers to a side or portion of an implant that must be oriented towards a top (for example, the head) of the body while the lower one refers to a side or portion of an implant that is intended to be oriented to a bottom of the body. Reference is also made here to the sides or side portions of an implant, which are sides or portions facing along the lateral directions of the body after implantation.
[0054] Figures 3-4 illustrate isometric views of a
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10/51 implant 100 modality. Specifically, Figure 3 is a posterior isometric view while Figure 4 is an anterior isometric view. In Figures 3-4, the implant 100 is understood to be configured with an anterior side 110 and a posterior side 112. The implant 100 can also include a first lateral side 114 and a second lateral side 116 that extend between the posterior side 112 and the front side 110 on the opposite sides of the implant 100. In addition, the implant 100 can also include an upper side 130 and a lower side 140.
[0055] The implant 100 can also be associated with several edges that are located at the intersections between the various sides. For example, the top side 130 and the first side side 114 can be on an upper side edge. Likewise, the bottom side 140 and the first side side 114 can be on a bottom side edge. It can be appreciated that the term edge as used herein is not limited to a precise contour of the implant 100 and is used to refer to a general region close to the intersection of two sides or faces of the implant 100.
[0056] Reference is also made to the directions or axes related to the implant itself, and not to the intended orientation in relation to the body. For example, the term distal refers to a part that is located farthest from the center of an implant, while the term proximal refers to a part that is located closest to the center of the implant. As used herein, the center of the implant can be the center of mass and / or a central plane and / or another centrally located reference surface.
[0057] An implant can also be associated with several
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11/51 axes. Referring to Figure 3, the implant 100 can be associated with a lateral axis 111 that extends along the implant 100 between the first lateral side 114 and the second lateral side 116. In addition, the implant 100 can be associated with an axis posterior-anterior 113 which extends between the posterior side 112 and the anterior side 110. In addition, the implant 100 can be associated with a vertical axis 115 (which can also be called the upper-lower axis) that extends along the implant thickness dimension 100 and which is generally perpendicular to the lateral axis 111 and the posterior-anterior axis 113 [0058] An implant can also be associated with several reference planes or surfaces. As used here, the term median plane refers to a vertical plane that passes from the anterior side to the posterior side of the implant, dividing the implant into right and left halves, or lateral halves. As used here, the term transverse plane refers to a horizontal plane located in the center of the implant that divides the implant into upper and lower halves. As used here, the term coronal plane refers to a vertical plane located in the center of the implant that divides the implant into anterior and posterior halves. In some modalities, the implant is symmetrical around two planes, such as the transversal plane.
[0059] The implant 100 is composed of one or more members of the body attached to one or more elements of bone contact. In the embodiments shown in Figures 3-4, the implant 100 includes a first body member 120 and a second body member 122. Each body member generally comprises a block-like member forming an end or solid side for the
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12/51 implant 100. In the exemplary embodiment, the first body member 120 is disposed at the anterior end of the implant 100, while the second body member 122 is disposed at the posterior end of the implant 100. Alternatively, in other embodiments, the implant 100 it may comprise one or more members of the body on either side extending between the first body member 120 and the second body member 122.
[0060] In different modalities, the geometry of one or more members of the body can vary. In some embodiments, the first body member 120 may comprise a solid structure including several connected faces. As seen in Figure 4, as well as in Figure 8, the first body member 120 includes the outer surface 121 which is further composed of a central face 150, a first angled face 151 and a second angled face 152. In addition, the first Body member 120 includes an inner surface 155 with a central face 156, a first angled face 157 and a second angled face 158 (see Figure 8). As best seen in Figure 8, the angles between these faces are selected to provide the first body member 120 with a wide, flat front side, in addition to creating a thicker central region 180 that can retain a fastener and / or the tip of a deployment tool.
[0061] In some embodiments, the second body member 122 may comprise a solid structure with a flat outer surface and a rounded inner surface. As seen in Figure 8, the second body member 122 includes a flat or flat outer surface 123 and a partially rounded inner surface 161. The geometry of the
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13/51 second body member 122 has a smooth, flat posterior surface for insertion while creating a thicker central region along the inside of the implant 100 that can hold fasteners, implantation tools or other arrangements used in fixing, aligning and / or device deployment.
[0062] In some embodiments, variations in height or vertical thickness between the first body member 120 and the second body member 122 may allow an implant with hyperlordotic angles between the lower and upper surfaces. In other embodiments, variations in vertical thickness can be used to control the relative stiffness of the device in different locations. In other embodiments, the first body member 120 and the second body member 122 may have substantially similar heights.
[0063] Some modalities may include one or more provisions for receiving fasteners. In some embodiments, an implant may include one or more threaded cavities. In some embodiments, a threaded cavity can be configured to match a corresponding threaded tip on a tool or implantation device. In other embodiments, a threaded cavity may receive a fixative for the purpose of fixing an implant to another device or component in an implantation system that uses multiple implants and / or multiple components.
[0064] As best seen in Figure 4, implant 100 includes a threaded cavity 170 disposed in the first body member 120. In some embodiments, the threaded cavity 170 can receive the threaded tip of a tool
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14/51 deployment (not shown). Such a tool could be used to drive the implant 100 between adjacent vertebral bodies.
[0065] In some embodiments, the first body member 120 and the second body member 122 can be joined by one or more bone contact elements. In the embodiment shown in Figures 3-4, the implant 100 includes a plurality of bone contact elements 200 that can be connected, and / or continuously formed (or integrally formed) with the first body member 120 and / or the second body member body 122.
[0066] As used herein, each bone contact element comprises a distinct member or element that encompasses a region or area of an implant. In some embodiments, these elements may overlap or intersect, similar to elements on a lattice or other 3D mesh structure. In other modalities, the elements cannot overlap or intersect. Some modalities may use elongated elements, in which the length of the element is greater than its width and thickness. For example, in the modalities in which an element has an approximately circular cross-sectional shape, the element is longer than its diameter. In the embodiments seen in Figures 3-4, each bone contact element is seen to have an approximately rounded or circular cross-sectional shape (i.e. the element has the geometry of a solid tube) along at least a portion of the element. However, in other embodiments, an element may have any other form of cross section, including, but not limited to, various forms of section
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15/51 polygonal (eg triangular, rectangular, etc.), as well as any other regular shape and / or irregular cross shapes. An example of a modality including a bone contact element with a rectangular cross-sectional shape is shown in Figures 24-25 and discussed in more detail below. In some cases, for example, the shape of the cross-section of an element in bone contact may vary along its length (for example, the diameter may change along its length).
[0067] Geometry of bone contact elements [0068] Modalities may include provisions to protect bone growth along and adjacent to bone contact elements of an implant. In some embodiments, a bone contact element can be configured with a geometry that helps to protect new bone growth in selected regions that can be referred to as protected fusion zones. In a protected fusion zone, new bone growth can be partially protected from resistances transmitted directly between the vertebrae and the bone contact surfaces of an implant, thereby increasing the rate at which new bone growth can spread through the implant.
[0069] In some embodiments, a bone contact element may have a spiral, helical or twisted geometry that provides a series of these protected fusion zones to improve bone growth. In other embodiments, a bone contact element can have a flat wavy geometry (for example, sinusoidal) which can also create protected fusion zones. In some embodiments, an implant may include bone contact elements with a geometry
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16/51 helical and other bone contact elements with a sinusoidal or flat wavy geometry.
[0070] Some bone contact elements may have a generalized helical geometry. As used here, a generalized helical geometry or spiral geometry refers to a geometry where a part (part, member, etc.) curls, rotates, twists, rotates or is curved around a fixed path. In some cases, the fixed path can be straight. In other cases, the fixed path can be curved. In the present embodiments, for example, the fixed path is generally a combination of straight and curved segments.
[0071] Curves with a generalized helical geometry (also called generalized helical curves) can be characterized by coils, turns or windings over a fixed path. Exemplary parameters that can characterize the specific geometry of a generalized helical curve can include the diameter of the coil (including the largest and smallest diameter) and the pitch (that is, spacing between adjacent coils). In some cases, the width of a coil or loop can also be used to describe the diameter or width of the coil or loop. Each of these parameters can be constant or vary over the length of a generalized helical curve.
[0072] Generalized helical curves need not be circular or even round. In some embodiments, for example, a generalized helical curve may have a linearly segmented shape (or locally polygonal shape), so that each coil or loop is
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17/51 composed of straight line segments, instead of arcs or other curved segments. Generalized helical curves can also include combinations of curved and straight segments. Examples of generalized helical curves are shown and described in 0 Application for Protected Fusion Zones.
[0073] For the purpose of characterizing the geometry of one or more bone contact elements, each bone contact element can be identified with one or more curves. Each bone contact element can be identified with a central curve. The central curve of each bone contact element can be defined as a curve that extends along the length (or longest dimension) of the bone contact element, so that each point along the curve is positioned centrally within the bone element. bone contact. In addition, each bone contact element can be identified with one or more curves on the outer surface. An external surface curve of a bone contact element can be defined as a curve that extends along the length (or longest dimension) of the bone contact element, so that each point along the curve is positioned on the external surface. .
[0074] Figure 5 is a schematic view of an exemplary bone contact element 202 of implant 100. For reference purposes, bone contact element 202 is shown in isolation from other parts of implant 100. As seen in Figure 5 , the bone contact element 202 exhibits twisted geometry indicative of a spiral or helix (i.e., generally helical geometry). Specifically, one or more segments of a central curve 210 of bone contact element 202 (referred to as
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18/51 winding) are seen rotating or twisting around the fixed path 220.
[0075] In some embodiments, a bone contact element may have a cross-sectional diameter that is greater than its winding diameter. Such a modality is discussed in the Request for Protected Fusion Zones. In the embodiment shown in Figure 5, the bone contact element 202 is seen to have a cross-sectional diameter 224 that is less than the winding diameter 222 of its central curve 210.
[0076] Generally, a bone contact element may not have a generalized helical geometry over its entire length. In other modalities, for example, its central curve can be configured with a winding segment in which the central curve completes several complete turns around a fixed path. Away from the winding segment, its central curve may not include turns, twists, etc.
[0077] Although the present modality includes at least one bone contact element with a winding segment that makes one or more complete turns around a fixed path, other modalities can be configured with curves
central that just make turns partial around one fixed route. [0078] Although the description here have if focused at geometry of a single element of contact bony, can to be
appreciated that other elements of bone contact may exhibit generally similar helical geometries. It can also be noted that two different bone contact elements may have slightly different geometries, with different central curves that include variations in the number of windings,
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19/51 in the form of the windings, etc.
[0079] In some embodiments, the bone contact elements can be characterized as having a wavy plane geometry. As used here, the term wavy plane geometry refers to a geometry in which the central curve of an element ripples (for example, waves or oscillates) in a single plane. In other words, the central curve is a flat wavy curve. A specific example of a wavy planar curve is a sinusoidal curve, although the term wavy planar curve is not restricted to curves that wave regularly like sinusoidal curves. This wavy plane geometry is distinguished from a generally helical geometry, since the generally helical curves do not
limit to one[0080] A singleFigure plan. 6 is an schematic view in one element contact bony 302 in an implant 100. For ends in reference, the element in bone contact 302 is shown in
solid lines, while the remaining parts are shown in phantom. Figure 7 is a schematic top-down view of implant 100, in which bone contact elements with generally helical geometries have been removed for clarity.
[0081] With reference to Figures 6-7, the bone contact element 302 exhibits a wavy plane geometry. Specifically, a central curve 310 of the bone contact element 302 is a planar curve (i.e., confined in this case to the plane 330) and includes at least one undulation. In addition, the bone contact element 305, which is disposed on an opposite side of the implant 100, is also seen in Figure 7 to have a wavy plane geometry. In some
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20/51 modalities, including the modality shown in Figure 7, the bone contact element 302 and the bone contact element 305 can have identical geometries and can be symmetrically mirrored around the median plane of the implant 100.
[0082] It can be appreciated that, in some modalities, a bone contact element may have a combination geometry. For example, in some cases, a bone contact element may include at least one segment with a generally helical geometry and at least one segment with a wavy plane geometry.
[0083] Arrangement of bone contact elements [0084] Modalities may include provisions to provide resistance to an implant, maximizing the volume available in and around the implant for bone graft. Some modalities may use bone contact elements generally helical that are arranged in configurations that increase support throughout an implant while also increasing the number of protected fusion zones available.
[0085] Figure 8 is a top-down view of an embodiment of implant 100, while Figure 9 is a side view of implant 100. With reference to Figure 8, implant 100 includes an upper set of bone contact elements 410. Each bone contact element in the upper set of bone contact elements 410 includes one or more segments having a generally helical geometry.
[0086] Each bone contact element can extend between the first body member 120 and the second body member 122. For example, a first bone contact element
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21/51
411 extends from the first body member 120 to the second body member 122 along the first side side 114 of the implant 100. More specifically, the first bone contact element 411 includes a first end
412 attached to a central region 180 of the first body member 120. A first wavy segment 414 of the first bone contact element 411 extends from the central region 180 to the first lateral side 114, at which point the first bone contact element 411 rotates to extend downward along the first side side 114. On the second body member 122, the first bone contact element 411 rotates again and a second corrugated segment 416 extends from the first side side 114 on the second body member 122 for the central region 182 of the second body member 122. Here, the first bone contact element 411 ends at a second end 418.
[0087] The second bone contact element 421 extends along the second opposite side side 116 of the implant 100. Specifically, in the modality shown in Figure 8, the second bone contact element 421 is symmetrically configured in mirror from the first bone contact element 411 around the median plane (represented in Figure 8 by the median plane axis 499).
[0088] Adjacent to the first bone contact element 411 is a third bone contact element 431. A first end 432 of the third bone contact element 431 is attached to the central region 180 of the first body member 120. In some embodiments, the first end 432 is fixed closer to the median plane than the first end 412 of the first bone contact element 411.
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22/51
From the first end 432, the third bone contact element 431 extends laterally and longitudinally until it comes in contact with the first bone contact element 411. At this point of contact, the third bone contact element 431 rotates and extends to the second member body 122, with a second end 438 attached to the second body member 122. As seen in Figure 8, the second end 438 of the third bone contact element 431 is arranged closer to the median plane than the second end 418 of the first element bone contact area 411 is in the median plane.
[0089] The fourth bone contact element 441 extends along the opposite side of the implant 100 from the third bone contact element 431. Specifically, in the embodiment shown in Figure 8, the fourth bone contact element 441 is configured in a way mirror mirror image from the third bone contact element 431 around the median plane.
[0090] Adjacent to the third bone contact element 431 is the fifth bone contact element 451. A first end 452 of the fifth bone contact element 451 extends from a recessed region 439 of the third bone contact element 431 and continues longitudinally (while spiraling) up to the second body member 122. A second end 458 of the fifth bone contact element 451 connects to the central region 182 of the second body member 122. Alternatively, in some embodiments, the second end 458 of the fifth element contact bone 451 can connect directly to a portion of the third bone contact element 431.
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23/51 [0091] The sixth bone contact element 461 extends along the opposite side of the implant 100 from the fifth bone contact element 451. Specifically, in the modality shown in Figure 8, the sixth bone contact element 461 is configured symmetrically in a mirror from the fifth bone contact element 451 around the median plane.
[0092] As seen in Figure 8, the fifth bone contact element 451 can be positioned closer to the median plane than the first bone contact element 411 and the third bone contact element 431. Likewise, the sixth contact element bone 461 can be positioned closer to the median plane than the fourth bone contact element 441 and the second bone contact element 421. Thus, the fifth bone contact element 451 and the sixth bone contact element 461 are positioned to provide support through the center of the implant 100 (where the center here refers to the center in relation to the lateral direction of the implant).
[0093] Using this exemplary configuration, the first bone contact element 411 and the second bone contact element 421 provide support along the lateral sides of the implant 100. The fifth bone contact element 451 and the sixth bone contact element 461 provide support in the center of implant 100. In addition, the present configuration uses the third bone contact element 431 and the fourth contact element 441 as additional supports that distribute loads between the outermost bone contact elements (ie, first contact element bone 411 and second bone contact element 421) and the innermost bone contact elements (ie, fifth bone
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24/51 bone contact 451 and sixth bone contact element 461). The use of helical elements to facilitate central and lateral support instead of straight or simply curved beams or supports allows an increase in the number of protected fusion zones provided throughout the implant 100.
[0094] It can be understood that in some modalities, one or more elements of bone contact from an upper side of an implant can come into contact with one or more elements of bone contact from an inferior side of an implant. In some embodiments, bone contact elements positioned centrally on the upper and lower sides of an implant can connect to each other adjacent to the transverse plane. In one embodiment, for example, the fifth bone contact element 451 and the sixth bone contact element 461 may include portions that extend to the transverse plane and connect with the corresponding portions of the bone contact elements arranged on the underside of the implant 100 In some cases, these connections can help improve vertical strength, especially in a central region of the implant.
[0095] To provide protected fusion zones along the lateral sides of a device while reinforcing the implant along the transverse plane, the modalities can use bone contact elements that undulate in a single plane. As seen in Figure 9, the first side side 114 of the implant 100 incorporates the bone contact element 302. The bone contact element 302 has a wavy plane geometry, as discussed earlier and shown in Figures 6-7.
[0096] With reference to Figure 9, the contact element
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Bone 25/51 302 extends from the first body member 120 to the second body member 122 on the first side side 114. In addition, the bone contact element 302 is arranged between, and provides support for, the first contact element bone 411 on the upper side 130 as well as a corresponding bone contact element 481 on the lower side 140.
[0097] The bone contact element 305 extends from the first body member 120 to the second body member 122 on the side side 116 (see Figure 7). In addition, bone contact element 305 is disposed between and supports the second bone contact element 421 on the upper side 130 as well as a corresponding bone contact element (not shown) on the lower side 140.
[0098] Using this arrangement, the bone contact element 302 and the bone contact element 305 provide peripheral support for the implant 100. Specifically, these elements provide attachment points for supporting helical bone contact elements located on the sides of the implant 100. In addition, the use of elements that curl in the transverse plane and of the implant 100 also creates protected fusion zones for new bone growth on the sides of the sides of the implant 100.
[0099] The use of helical elements on the top and bottom sides of an implant together with wavy planar elements along the transverse plane provides a layered structure unique to the 100 implant. As best seen in Figure 9, some modalities can be characterized by a central layer 470 of wavy flat bone contact elements sandwiched between an upper layer 472 of generally helical bone contact elements and a
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26/51 lower layer 474 of bone contact elements generally helical.
[00100] In some embodiments, the top layer 472 and the bottom layer 474 can be mirrored symmetrically around the transverse plane of the implant 100. In addition, each top layer 472 and bottom layer 474 can include six spirals each, as well as three spirals per quadrant.
[00101] Modalities can include one or more bone contact regions. Bone contact regions can be regions along a bone contact element and / or body member that are configured to directly contact a vertebral body or other adjacent bone or tissue after implantation. These regions can comprise most of the distal surfaces of an implant, including most of the distal surfaces on the top, bottom and side of the implant.
[00102] In different modalities, the geometry of one or more regions of bone contact can vary. In some embodiments, the regions of bone contact may be relatively smooth regions. In some cases, the bone contact regions can be relatively flat regions. In other embodiments, a bone contact region can be curved. In some cases, the bone contact region may have a curvature that corresponds to the curvature of the adjacent superficial regions of the outer limb. In other cases, the distal superficial region may have a different curvature (for example, more convex) than the adjacent superficial regions of the external member.
[00103] As seen in Figure 8, implant 100 includes a first plurality of bone contact regions 500
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27/51 arranged along the generally helical upper set of bone contact elements 410. The first plurality of bone contact regions 500 can be arranged in most distal parts of the upper set of bone contact elements 410, and thus configured to contact directly a corresponding vertebral surface after implantation. Although not shown, the bone contact elements on the lower side 140 of the implant 100 may also include a plurality of bone contact regions configured to directly contact an opposite vertebral surface.
[00104] As seen in Figure 9, implant 100 includes a second plurality of bone contact regions 502 that are arranged in the wavy flat bone contact element 302. The second plurality of bone contact regions 502 can be arranged in most parts distal from the bone contact element 302, and thus configured to directly contact any tissue disposed against the lateral sides of the implant 100 after implantation. Although not shown, the bone contact element 305 on an opposite side of the implant 100 can also include a plurality of bone contact regions.
[00105] In different modalities, the number of bone contact regions can vary. In some embodiments, an implant can include between 10 and 100 regions of bone contact. In other embodiments, an implant may include less than 10 regions of bone contact. In yet other modalities, an implant can include more than 100 regions of bone contact. In the exemplary embodiment of Figures 8-9, implant 100 can include approximately 42 to 46 contact regions
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Bone 28/51. Specifically, implant 100 includes approximately 20 regions of bone contact on the upper side 130, approximately 20 regions of bone contact on the lower side 140, approximately 1-3 regions of bone contact on the first lateral side 114 and approximately 1-3 regions of bone contact on the second side 116.
[00106] The use of bone contact elements with flat helical and / or wavy geometries can help facilitate new bone growth since the elements with these geometries naturally incorporate one or more protected fusion zones. These protected fusion zones generally occur at locations along the bone contact element that are located proximally to distal bone contact surfaces (ie, bone contact regions).
[00107] Connections between bone contact elements [00108] In different modalities, bone contact elements can connect to each other in several ways. Figure 10 is a schematic view of several different types of connections between bone contact elements. As seen in Figure 10, in an exemplary connection type 550, the end of a bone contact element 551 can connect to another bone contact element 552. In another exemplary connection type 560, two bone contact elements (this that is, element 561 and element 562) can intersect so that they pass through or transversely to each other. In yet another exemplary type of connection 57 0, a bone contact element 571 and a bone contact element 572 can form a tangential connection, in which the elements touch only along their side walls.
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29/51 [00109] Figure 11 is a schematic view of an embodiment of the implant 100 including an enlarged schematic view of a connection region 600 where two bone contact elements come into contact with each other. Referring to Figure 11, the enlarged region includes portions of the fifth bone contact element 451 and the sixth bone contact element 461. Here, the fifth bone contact element 451 includes a side wall 602 and the sixth bone contact element 461 includes a side wall 604. As used here, the term side wall refers to the outer wall or outer surface of the bone contact element, which extends between the opposite ends of the bone contact element.
[00110] As seen in Figure 11, the side wall 602 of the fifth bone contact element 451 and the side wall 604 of the sixth bone contact element 461 rotate and touch before moving away from each other. Specifically, side wall 602 and side wall 604 come into contact at connection part 610. In addition, side wall 602 and side wall 604 are separated at all locations away from connection region 600.
[00111] In some cases, the bone contact elements can cross perpendicularly. An example occurs when the first end 452 of the fifth bone contact element 451 attaches to a portion of the third bone contact element 431. In contrast, in the connection region 600 the fifth bone contact element 451 and the sixth bone contact element 461 are tangential to each other. Specifically, the central curve 620 of the fifth bone contact element 451 and the central curve 622 of the sixth bone contact element
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30/51 bone contact 461 are approximately parallel in connection portion 610.
[00112] The use of tangential connections between the bone contact elements allows to increase the lateral resistance minimizing or eliminating the need for separate support elements that pass laterally through an implant. Specifically, in the embodiment of Figure 11, the fifth bone contact element 451 and the sixth bone contact element 461 can be attached, and provide lateral support, to each other while also extending mainly in a longitudinal direction between the first body member 120 and the second body member 122. Likewise, other bone contact elements of the implant 100 can be configured so that they connect along its side walls. For example, in the embodiment shown in Figure 11, implant 100 includes the second tangential connection portion 652 between the first bone contact element 411 and the third bone contact element 431; and third tangential connection portion 654 between the third bone contact element 431 and the fifth bone contact element 451. It can be appreciated that similar tangential connections may be present on the underside of the implant 100.
[00113] In some embodiments, tangential connections may occur between elements of bone contact generally helical and elements of wavy plane bone contact. With reference to Figure 12, which shows a schematic isometric view of the implant 100, several exemplary tangential connections are highlighted. These include tangential connection 662, tangential connection 664 and tangential connection 666, which
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31/51 are all tangential connections between the first bone contact element 411 and bone contact element 302. Additional tangential connections can occur between bone contact element 302 and bone contact element 481 on the underside 140 of the implant 100. It can be appreciated that similar tangential connections between helical elements and flat corrugated elements may be present on the second opposite side side 116.
[00114] In some embodiments, there may be a relationship between the oscillation patterns of a generally helical element and an adjacent wavy flat element. In some cases, the peaks (for example, more distal parts) of a helical element may correspond to the peaks (for example, distal parts) of a wavy flat element. For example, the peaks of both types of elements can have a similar longitudinal position along the posterior-anterior axis 113. In other cases, the peaks can be shifted so that the peaks of a helical element correspond to the valleys (i.e. , closest portions) of a flat wavy element. In still other cases, the peaks can be displaced so that the peaks of a helical element are somewhere between the peaks and valleys of a wavy flat element.
[00115] In the embodiment shown in Figure 9, the bone contact element 411 includes several bone contact regions 540, which are associated with the peaks or more distal portions of the first bone contact element 411. Likewise, the contact element bone 302 includes several second plurality of bone contact regions 502, which are associated with the peaks or more distal portions of the
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32/51 bone contact 302. Here, the peaks are seen as displaced, with the second plurality of bone contact regions 502 having different longitudinal positions from regions of bone contact 540. With this arrangement, the corresponding protected fusion zones 542 in the first bone contact element 411 they are displaced from the protected fusion zones 544 in the bone contact element 302. This can help to prevent new bone growth from growing initially growing along the side bands (that is, bands with common longitudinal position) along the lateral sides of the implant 100.
[00116] In different modalities, the amplitude (or winding diameter) of bone contact elements generally helical can vary. In some embodiments, a first generally helical bone contact element may have a greater amplitude than a second generally helical bone contact element. In other embodiments, each bone contact element generally helical in an implant can have a similar amplitude.
[00117] In one embodiment, shown in Figure 13, the first bone contact element 411 has an amplitude 702 (or winding diameter) that is greater than an amplitude 704 of the third bone contact element 431. In addition, the fifth element of bone contact 451 is seen to have an amplitude 706 which is also greater than the amplitude 704 of the third bone contact element 431. This arrangement allows the third bone contact element 431, with its relatively smaller amplitude, to distribute mainly lateral loads between the first bone contact element 411 on the lateral side of the implant 100 and the fifth
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33/51 bone contact 451, which is centrally located on implant 100.
[00118] Surface texturing [00119] Modalities may include provisions for texturing one or more surfaces of an implant. This texture can increase or promote bone growth and / or fusion on the implant surfaces. In some embodiments, bone contact elements and / or sections of a body can be textured.
[00120] In some embodiments, the surface structure of one or more regions of an implant may be rough or provided with irregularities. Generally, this rough structure can be achieved through the use of acid etching, blasting of spheres or grains, spray coating with titanium, titanium sintering spheres or cobalt chromium on the implant surface, as well as other methods. This can result in a prosthesis with a roughness of the surface with about 3-5 microns of peak roughness to the valley. However, in some embodiments, the surface roughness may be less than 3-5 microns peak to valley, and in other embodiments, the surface roughness may be greater than 3-5 microns peak to valley.
[00121] Figure 14 is a schematic isometric view of an embodiment of an implant 800 including a plurality of bone contact elements 802. The implant 800 is configured with surface texturing 804, which is represented using dotted lines. In some embodiments, some portions of the 800 implant may have surface textures. In other embodiments, all portions of the 800 implant may have surface textures. In the modality
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34/51 depicted in Figure 14, surface texturing 804 is applied to most of the implant 800. However, at least some portions do not include surface textures, including the posterior surface 806 of the posterior member of the body 808. This can help prevent bone growth from developing towards the spine. In some cases, an anterior surface (not shown) may also lack texture on the surface.
[00122] Additional modalities [00123] Modalities may include provisions to modify the resistance of an implant in one or more directions to better support various loads, such as the vertical load applied by adjacent vertebrae. In some embodiments, the shape and / or size of one or more bone contact elements can be modified to vary the strength of the implant on one or more sides and / or along one or more directions. In other embodiments, additional support structures can be incorporated into an implant to reinforce one or more sides. In some cases, for example, modalities can incorporate one or more support walls, for example, on the lateral sides of an implant, which can cross one or more elements of bone contact.
[00124] Figures 15-20 illustrate schematic views of another modality of an implant 1000. Referring first to Figures 15-18, implant 1000 can be configured with similar arrangements to implant 100. For example, implant 1000 can generally include a first body member 1002 and a second body member 1004 which are connected by several bone contact elements 1010. The first body member 1002 can comprise a face
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Generally smooth and flat anterior 35/51 1020, which further includes a recessed region 1022 and a threaded opening 1024. In addition, the second body member 1004 is seen to have a generally smooth and flat posterior face 1026.
[00125] The implant 1000 also comprises bone contact elements generally helical arranged on the upper side 1008 (see Figures 15-16) and on the opposite side 1009. On the upper side 1008, as best seen in Figure 17, the bone contact elements 1010 include a first bone contact element 1011, a second bone contact element 1012, a third bone contact element 1013, a fourth bone contact element 1014, a fifth bone contact element 1015 and a sixth bone contact element 1016, which can be arranged in approximately the same way as the first bone contact element 411, the second bone contact element 421, the third bone contact element 431, the fourth bone contact element 441, the fifth bone contact element 451 and the sixth bone contact element 461, respectively, of implant 100. This similar configuration includes, for example, places where adjacent elements of bone contact connect tangentially (that is, along their respective side walls). It may be appreciated that in some embodiments the lower side 1009 may include a mirrored symmetrical arrangement of bone contact elements from those on the upper side of 1008.
[00126] In some embodiments, implant 1000 may include provisions that increase vertical strength or support for the device. Referring now to the side view shown in Figure 18, a support wall
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1050 can be arranged in the region between the first bone contact element 1011 on the upper side 1008 and a second bone contact element 1061 on the lower side 1009.
[00127] In some embodiments, a support wall can be used with a wavy flat bone contact element to increase vertical strength. In Figure 18, implant 1000 is seen to include a wavy flat bone contact element 1070 that extends along the transverse plane and provides support for bone contact element 1011 and the second bone contact element 1061. In addition, the element of wavy flat bone contact 1070 is seen to intersect with the support wall 1050.
[00128] Figures 19 and 20 are schematic views of the support wall 1050 and a corrugated flat bone contact element 1070 that extends from opposite surfaces of the support wall 1050. With reference to Figures 19-20, the element of corrugated flat bone contact 1070 is an integral part of the support wall 1050. A first bone contact region 1072 and a second bone contact region 1074 extend from an external side 1052 of the support wall 1050. Likewise, a region proximal 1076 of the wavy flat bone contact element 1070 extends from an inner side 1054 of the support wall 1050.
[00129] In different modalities, the properties of a support wall can be selected to achieve a desired degree of vertical resistance on the side of a device. In some embodiments, a support wall can extend across any open spacing between opposing helical bone contact elements on the side of an implant. In other embodiments, a support wall
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37/51 can extend only partially between the opposite helical bone contact elements, thus leaving openings or other gaps on the lateral side of an implant. In some embodiments, the thickness of a support wall may be greater than the diameter of the opposing helical elements. In other embodiments, the thickness of a support wall may be less than the diameter of the opposite helical elements. For example, it can be clearly seen in Figures 19-20 that the thickness 1056 of the support wall 1050 may be less than the diameter of the first generally helical bone contact element 1011.
[00130] Using this arrangement, a lateral side of the implant 1000 can be provided with vertical support from an additional support wall 1050, maintaining at least one region 1080 to protect the new bone growth (see Figure 18). Specifically, region 1080 is seen as indented from the first bone contact region 1072 of the bone and the second bone contact region 1074.
[00131] Figures 21-25 illustrate schematic views of another modality of an implant 1200. Referring first to Figures 21-24, implant 1200 can be configured with similar arrangements to implant 100 and / or implant 1000. For example, implant 1200 can generally include a first body member 1202 and a second body member 1204 which are connected by various bone contact elements 1210. The first body member 1202 may comprise a generally smooth and flat front face 1220, which further includes a region recess 1222 and a threaded opening 1224. In addition, second body element 1204 is seen to have a generally flat and smooth back face 1226.
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38/51 [00132] The implant 1200 also comprises bone contact elements generally helical arranged on the upper side 1208 and on the opposite lower side 1209 (see Figures 21-22). On the upper side 1208, bone contact elements 1210 include a first bone contact element 1211, a second bone contact element 1212, a third bone contact element 1213, a fourth bone contact element 1214, a fifth bone contact element 1215 and a sixth bone contact element 1216, which can be arranged in a manner approximately similar to the first bone contact element 411, second bone contact element 421, third bone contact element 431, fourth bone contact element 441, fifth element bone contact 451 and sixth bone contact element 461, respectively, of implant 100. This similar configuration includes, for example, locations where adjacent bone contact elements connect tangentially (ie, along their respective side walls) . It can be appreciated that in some embodiments the lower side 1209 may include a mirror symmetrical arrangement of the bone contact elements from those on the upper side 1208.
[00133] In some embodiments, the geometry of a bone contact element can be selected to achieve a desired degree of vertical resistance for a device. In some embodiments, a bone contact element may have a cross-sectional shape that is elongated in a dimension aligned with the vertical direction (for example, the height of the element) in relation to a dimension aligned with the lateral direction (for example, the thickness of the element). In some embodiments, the shape of the cross section can be
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39/51 approximately elliptical. In other embodiments, the shape of the cross section can be approximately rectangular.
[00134] As seen in Figures 24, implant 1200 includes bone contact element 1260, which has a non-circular cross-sectional shape. In one embodiment, the bone contact element 1260 has a rectangular cross-sectional shape 1320. This is best shown in Figure 25, which illustrates a schematic view of the bone contact element 1260 isolated from implant 1200. As seen in Figure 25 , the bone contact element 1260 includes a height 1302 that is greater than its width 1304. By increasing the height of the bone contact element 1260 in relation to the size (for example, diameter) of the adjacent bone contact elements (i.e., element helical bone contact 1271 and helical bone contact element 1272), the overall resistance of implant 1200 under vertical load can be increased.
[00135] The bone contact element 1260 also has a wavy geometry. As best seen in Figure 25, an external surface curve 1310 of the bone contact element 1260 is seen as a flat wavy curve. Here, the curve of the outer surface 1310 can be defined by the intersection of a plane with the outer surface 1360 of the bone contact element 1260. It can be appreciated that, although the exemplary embodiment represents the bone contact element 1260 as having a wavy inner surface 1362 which corresponds to the curvature of the outer surface 1360, in other embodiments the inner surface 1362 may be relatively flat.
[00136] The wavy configuration shown in Figures 24-25 ensures that the bone contact element 1260 presents regions of bone contact 1266 on the lateral side of the implant
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1200 in addition to providing protected fusion zones 1268 located at locations between bone contact regions 1266.
[00137] Different modalities may vary in size. In some embodiments, the footprint of an implant may vary. As used herein, the footprint of the device comprises its approximate area in the transverse plane (or other horizontal plane). In some embodiments, an implant can be manufactured in two or more different footprint sizes. In some embodiments, an implant can be manufactured in three or more different footprint sizes, including a small, medium, and large footprint. Implants of different footprint sizes can be used to accommodate different sized vertebrae. In one embodiment, the footprint sizes can be as follows: a small footprint with dimensions of 12x14.5 mm; an average footprint with dimensions of 12.5 x 16 mm; and a large footprint with dimensions of 13xl8mm.
[00138] Different modalities can incorporate implants of different heights. For example, an implant can be manufactured at two or more different heights. In other embodiments, an implant can be manufactured at three or more different heights. In some embodiments, implants can be manufactured at any time in a range between approximately 5 and 12 mm. In some embodiments, an implant can be manufactured with a height of 5 mm, a height of 8 mm and a height of 12 mm. One embodiment of a 5 mm high device is shown in Figures 15-20. One embodiment of a 12 mm high device is shown in Figures 21-25.
[00139] Modalities can also be provided with
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41/51 various flat / parallel (0 degrees), lordotic and hyperlordotic angles. In some embodiments, the implant can be configured at an angle of approximately 8 degrees between the upper and lower surfaces. In other embodiments, the implant can be configured with an angle of approximately 15 degrees between the upper and lower surfaces. In yet other modalities, the implant can be configured with an angle of approximately 20 degrees between the upper and lower surfaces. Still other angles possibly include all angles in the range between 0 and 30 degrees. Still other modalities can provide a lordotic angle of less than 8 degrees. Still other modalities can provide a hyperlordotic angle of more than 20 degrees.
[00140] In different modalities, one or more sides of an implant can be configured with a predetermined curvature. In some embodiments, an upper and / or lower surface can be configured with a convex geometry that surrounds the concave geometry of the opposite vertebral surfaces. In other embodiments, however, the lower and / or upper surfaces of an implant can be concave, flat, tapered / angled to provide lordosis or kyphosis, etc. in shape.
[00141] Figures 26-36 illustrate several views of additional modalities of implants that can incorporate bone contact elements with generalized helical geometries and bone contact elements with wavy flat geometries. These modalities are representative of implants that can be configured with different dimensions and / or footprint heights. For example, the modality represented in Figures 26-29 can correspond to a
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42/51 implant with a large footprint (approximately 13xl8mm) and height of approximately 8mm. Likewise, the modality shown in Figure 30 can correspond to an implant with a large footprint and a height of approximately 10-12 mm. In addition, the modality shown in Figures 31-33 can correspond to an implant with a small footprint (approximately 12x14.5 mm) and a height of approximately 10-12 mm. The modality shown in Figures 34-36 can correspond to an implant with a small footprint and a height of approximately 5-6 mm.
[00142] Figures 26-29 illustrate several schematic views of one embodiment of a 1400 implant. The 1400 implant can share similar arrangements with one or more of the previous embodiments of Figures 1-25. Referring to Figures 26-28, in some embodiments, the implant 1400 includes a first body member 1420 and a second body member 1422. In addition, a set of bone contact elements 1450 with a generally helical geometry can extend to from the first body member 1420 to the second body member 1422 on the upper side 1430 and on the lower side 1440. In addition, the implant 1400 may include a first peripheral bone contact element 1460 and a second peripheral bone contact element 1462 in the lateral sides of implant 1400, each of these elements having a wavy plane geometry.
[00143] As seen in Figure 27, the set of bone contact elements 1450 can include four generalized helical elements on the upper side 1430. These include a first upper bone contact element 1451, a second upper bone contact element 1452, a
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43/51 third upper bone contact element 1453 and a fourth upper bone contact element 1454, extending from the first body member 1420 to the second body member 1422.
[00144] Modalities may include provisions to increase the resistance along a lateral direction of an implant. In some embodiments, an implant may include one or more straight nails or beams arranged in a generally lateral direction through parts of an implant. In other embodiments, an implant may include one or more curved bone contact elements arranged along a lateral direction of an implant. In some cases, a bone contact element disposed laterally may have a generalized helical geometry. In other cases, a bone contact element disposed laterally may have a wavy plane geometry.
[00145] As seen in Figures 26 and 27, implant 1400 may include a central bone contact element 1470 that generally extends between the opposite side sides of implant 1400 (and therefore between the first peripheral bone contact element 1460 and the second peripheral bone contact element 1462). As seen in Figure 27, as well as in Figure 29 (showing the implant 1400 with the set of bone contact elements 1450 removed), the central bone contact element 1470 has a wavy flat geometry.
[00146] In some embodiments, one or more adjacent bone contact elements may have portions that align or are oriented along a section of the central bone contact element 1470. As best seen in Figure 27, the second element of upper bone contact 1452 has a portion
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44/51 central 1490 that is aligned (or parallel) with the adjacent portion of central bone contact element 1470. Likewise, the third upper bone contact element 1453 may include a central portion 1492 that is aligned (or parallel) with the adjacent portion of the central bone contact element 1470. This arrangement can improve strength by increasing the area to which each generalized helical element is attached to the central bone contact element 1470.
[00147] Furthermore, as seen in Figure 29, first peripheral bone contact element 1460, second peripheral bone contact element 1462 and central bone contact element 1470 can all be aligned in a common plane, such as the transverse plane of implant 1400 Specifically, a first end 1471 of the bone contact element 1470 attaches to a portion of the first bone contact element 14 60 and a second end 1472 of the central bone contact element 1470 attaches to a portion of the second bone contact element 1462 .
[00148] This configuration can help to strengthen the 1400 implant in the lateral direction, in addition to promoting bone growth within the interior of the 1400 implant. For example, the wavy plane geometry of the central bone contact element 1470 can create 1480 protected fusion zones between adjacent crests of the element, helping to minimize disturbances of new bone growth within those zones.
[00149] Figure 30 is a schematic isometric view of another modality of a 1500 implant. The 1500 implant can share many arrangements with the 1400 implant. In some embodiments, the 1500 implant includes a first
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45/51 body member 1520 and a second body member 1522. In addition, a set of bone contact elements 1550 with a generally helical geometry can extend from the first body member 1520 to the second body member 1522 at upper side 1530 and lower side 1540. In addition, the implant 1500 may include a first peripheral bone contact element 1560 and a second peripheral bone contact element 1562 on the side sides of the implant 1500, each of these elements having a wavy flat geometry . In addition, implant 1500 may include a central bone contact element 1570 with a wavy flat geometry that extends laterally through implant 1500.
[00150] However, the 1500 implant can be configured with a height greater than the 1400 implant. To achieve a greater height, the height of the generally helical elements and / or wavy flat elements can be increased in relation to their heights, for example , in the 1400 implant. In the exemplary embodiment, the peripheral bone contact element 1560 has a height 1585 that can be greater than a height 1485 of the peripheral bone contact element 1460 of the implant 1400 (see Figure 29). In addition, the height 1585 of the bone contact element 1560 in relation to its width may be greater than the height 1485 of the element 1460 in relation to its width. Thus, it can be appreciated that the general dimensions of the corrugated flat elements can vary to achieve different strength characteristics.
[00151] In different modalities, the geometry and / or arrangement of one or more elements can be modified to vary the lateral resistance. Figures 31-33 illustrate
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46/51 several schematic views of a 1600 implant. The 1600 implant can share many arrangements with implant 1400 and / or implant 1500. In some embodiments, implant 1600 includes a first body member 1620 and a second body member 1622. In addition, a set of bone contact elements 1650 with a generally helical geometry can extend from the first body member 1620 to the second body member 1622 on the upper side 1630 and on the lower side 1640. In addition, the implant 1600 may include a first peripheral bone contact element 1660 and a second peripheral bone contact element 1662 on the side sides of the implant 1600, each of these elements having a wavy plane geometry.
[00152] In contrast to implant 1400, implant 1600 may include a side support element 1680 that has a different geometry from the bone contact element 1470. For example, side support element 1680 may be wider (in relative to the longitudinal direction) at its lateral ends (ie, ends 1681 and ends 1682). The width of the side support element 1680 can taper at the side ends to a central portion 1684, which connects to a bone contact element 1652 and a bone contact element 1654 of the set of bone contact elements 1650.
[00153] In order to further improve the lateral support, in some embodiments, the upper bone contact element 1652 and the upper bone contact element 1654 can be attached along a connecting portion 1686 extending from the element lateral support 1680 to a location directly adjacent to the bone contact regions
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47/51 located distally 1690.
[00154] In yet another embodiment, shown in several schematic views in Figures 34-36, it is seen that a 1700 implant lacks any elements that extend laterally between the sides of the 1700 implant (from the first body member 1720 and the second body member 1722). As seen in Figure 34, a set of upper bone contact elements 1735 can be directly connected to a set of lower bone contact elements 1745 adjacent to a transverse plane of the 1700 implant. In some embodiments, pairs of corresponding elements from these two sets can be attached to the central connection portions 1750. In the embodiment of Figures 34-36, a first central upper bone contact element 1761 is attached to a first central lower bone contact element 1771 and a second upper bone contact element 1762 is attached to a second central lower bone contact element 1772.
[00155] In addition to variations in height, footprint and lateral support, the modalities of Figures 26-36 all represent implants in which the bone contact elements generally helical on the upper and lower sides of the implant each include one or more regions of bone contact . For example, as best seen in the side view of Figure 28, the upper bone contact element 1451 and the lower bone contact element 1456 include both regions of bone contact 1459. Likewise, as best seen in the side view side of Figure 33, the implant 1600 also includes 1659 bone contact regions in the side face portions of the 1650 bone contact elements. Along with the contact regions
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48/51 bone arranged in wavy flat elements along the lateral sides of these implants, these additional bone contact regions can help provide a consistent lateral engagement surface between the implants and the bone tissue or other tissue after implantation.
[00156] Bone growth promotion material [00157] In some embodiments, bone growth can be facilitated by the application of bone growth promoting material in or around parts of an implant. As used here, a bone growth promoting material (or BGPM) is any material that helps bone growth. Bone growth promoting materials can include provisions that are lyophilized on a surface or adhered to the metal through the use of ligand molecules or a ligand. Examples of bone growth promoting materials are any materials including bone morphogenetic proteins (BMPs), such as BMP-1, BMP-2, BMP4, BMP-6 and BMP-7. These are hormones that convert stem cells into bone-forming cells. Other examples include recombinant human BMPs (rhBMPs), such as rhBMP-2, rhBMP-4 and rhBMP-7. Still other examples include platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), collagen, BMP mimetic peptides, as well as RGD peptides. Generally, combinations of these chemicals can also be used. These chemicals can be applied using a sponge, matrix or gel.
[00158] Some bone growth promotion materials can also be applied to an implantable prosthesis through the use of a plasma spray or electrochemical techniques.
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49/51
Examples of these materials include, but are not limited to, hydroxyapatite, tri-calcium beta phosphate, calcium sulfate, calcium carbonate, as well as other chemicals.
[00159] A bone growth promoting material may include, or may be used in combination with, a bone graft or a bone graft substitute. A variety of materials can serve as bone grafts or bone graft substitutes, including autografts (harvested from the iliac crest of the patient's body), allografts, demineralized bone matrix, and various synthetic materials.
[00160] Some modalities may use autograft. The autograft provides calcium collagen scaffolds to the medullary fusion for the new bone to grow (osteoconduction). In addition, the autograft contains bone growth cells, mesenchymal stem cells and osteoblasts that regenerate bone. Finally, the autograft contains bone growth proteins, including bone morphogenic proteins (BMPs), to promote new bone growth in the patient.
[00161] Bone graft substitutes may comprise synthetic materials including calcium phosphates or hydroxyapatites, products containing stem cells that combine stem cells with one of the other classes of bone graft substitutes, and matrices containing growth factors such as INFUSE® (graft bone containing rhBMP-2) from Medtronic, Inc.
[00162] It should be understood that the provisions listed here are not intended to be an exhaustive list of possible bone growth promotion materials, bone grafts or bone graft substitutes.
Petition 870190121222, of 11/22/2019, p. 90/92
50/51 [00163] In some modalities, BGPM can be applied to one or more external surfaces of an implant. In other modalities, BGPM can be applied to internal volumes within an implant. In still other modalities, BGPM can be applied to both external and internal surfaces within an implant.
[00164] Fabrication and Materials [00165] The various components of an implant can be manufactured from biocompatible materials suitable for implantation in a human body, including but not limited to, metals (for example, titanium or other metals), synthetic polymers , ceramics and / or their combinations, depending on the application and / or preference of a doctor.
[00166] Generally, the implant can be formed from any biocompatible material, and not suitable degradable with sufficient strength. Typical materials include, but are not limited to, titanium, biocompatible titanium alloys (eg, titanium aluminides, Ti 6 Al 4 -V ELI (ASTM F 136) or Ti 6 -Al 4 -V (ASTM F 1108 and ASTM F 1472 )) and inert and biocompatible polymers, such as polyether ether ketone (PEEK) (for example, PEEK-OPTIMA®, Invibio Inc). Optionally, the implant contains a radiopaque marker to facilitate visualization during the image.
[00167] In different modalities, the processes for making an implant can vary. In some embodiments, the entire implant can be manufactured and assembled through injection molding, injection molding or molding, insertion molding, co-extrusion, pultrusion, transfer molding, overmolding, compression molding, three-dimensional (3-D) printing ), dip coating,
Petition 870190121222, of 11/22/2019, p. 91/92
51/51 spray coating, powder coating, porous coating, milling from a solid material and their combinations. In addition, the modalities can make use of any of the resources, parts, assemblies, processes and / or methods disclosed in 0 Spiral Implant Order.
[00168] Although several modalities have been described, the description is intended to be exemplary, rather than limiting, and it will be evident to people of ordinary skill in the art that many more modalities and implementations that are within the scope of the modalities are possible. Although many possible combinations of features are shown in the attached figures and discussed in this detailed description, many other combinations of the disclosed features are possible. Any feature of any modality may be used in combination with or replaced by any other feature or element in any other modality unless specifically restricted. Therefore, it will be understood that any of the features shown and / or discussed in the present disclosure can be implemented together in any suitable combination. Therefore, the modalities should not be restricted except in light of the attached claims and their equivalents. In addition, various modifications and changes can be made within the scope of the attached claims.

权利要求:
Claims (27)
[1]
1. Implant, characterized by the fact that it comprises:
one first member of body and one second member in body; one first element in contact bony by having an first side wall; one second element in contact bony by having an
second side wall;
the first bone contact element extending from the first body member to the second body member;
the second bone contact element extending from the first body member to the second body member; and wherein the first side wall of the first bone contact element is attached to the second side wall of the second bone contact element in a connecting portion.
[2]
2. Implant, according to claim 1, characterized by the fact that the first bone contact element is tangent to the second bone contact element in the connecting portion.
[3]
3. Implant, according to claim 1, characterized by the fact that the first bone contact element has a generally helical geometry.
[4]
4. Implant, according to claim 3, characterized by the fact that the second bone contact element has a generally helical geometry.
[5]
5. Implant, according to claim 3, characterized by the fact that the second element of
Petition 870190090779, of 12/09/2019, p. 15/21
2/6 bone contact has a flat wavy geometry.
[6]
6. Implant, according to claim 4, characterized by the fact that the first bone contact element and the second bone contact element are located adjacent to a median plane of the implant.
[7]
7. Implant, according to claim 4, characterized by the fact that the first bone contact element has a greater winding diameter than the second bone contact element.
[8]
8. Implant, according to claim 1, characterized by the fact that:
the implant includes a lower side and an upper side;
wherein the implant includes at least six bone contact elements with a generally helical geometry on the upper side;
wherein the implant includes at least six bone contact elements with a generally helical geometry on the underside; and wherein each of the bone contact elements on the upper side and on the lower side extends from the first body member to the second body member.
[9]
9. Implant, according to claim 1, characterized by the fact that:
the first body member is disposed at an anterior end of the implant and the second body member is disposed at a posterior end of the implant.
[10]
10. Implant, characterized by the fact that it comprises:
Petition 870190090779, of 12/09/2019, p. 16/21
3/6 a first body member and a second body member;
a bone contact element extending from the first body member to the second body member; and wherein the bone contact element has a wavy plane geometry.
[11]
11. Implant, according to claim 10, characterized by the fact that the implant includes at least one bone contact element with a generally helical geometry.
[12]
12. Implant, according to claim 10, characterized by the fact that the bone contact element crosses a transverse plane of the implant.
[13]
13. Implant, according to claim 10, characterized by the fact that the bone contact element is disposed between a first generally helical bone contact element and a second generally helical bone contact element.
[14]
14. Implant, according to claim 10, characterized by the fact that the bone contact element has a circular cross-sectional shape.
[15]
15. Implant, according to claim 10, characterized by the fact that the bone contact element has a rectangular cross-sectional shape.
[16]
16. Implant, according to claim 10, characterized by the fact that a central curve of the bone contact element has wavy plane geometry.
[17]
17. Implant, according to claim 10, characterized by the fact that a surface curve
Petition 870190090779, of 12/09/2019, p. 17/21
4/6 outer bone contact element has wavy plane geometry.
[18]
18. Implant, characterized by the fact that it comprises:
an upper side, a lower side and a lateral side;
a first body member and a second body member;
a first bone contact element extending from the first body member to the second body member, the first bone contact element being arranged adjacent to a location where the lateral side meets the upper side;
a second bone contact element extending from the first body member to the second body member, the second bone contact element being arranged adjacent to a location where the lateral side meets the underside;
an support wall what stretches on side side between the first element in contact bony it's the second element bone contact; and one third element in contact bony what cross the
support wall.
19. Implant, according with the claim 18, characterized by fact that the third element in bone contact has a geometry flat wavy. 20. Implant, according with the claim 19,
characterized by the fact that the intersection of the third bone contact element with the support wall forms a first region of raised bone contact and a second region of raised bone contact on the lateral side between the
Petition 870190090779, of 12/09/2019, p. 18/21
5/6 first bone contact element and the second bone contact element.
[19]
21. Implant, characterized by the fact that it comprises:
a first body member and a second body member;
a first direction extending from the first body member to the second body member and a second direction perpendicular to the first direction;
a central bone contact element that generally extends along the second direction; and wherein the central bone contact element has a wavy plane geometry.
[20]
22. Implant according to claim 21, characterized by the fact that the first body member is located on the anterior side of the implant, and the second body member is located on the posterior side of the implant.
[21]
23. Implant, according to claim 21, characterized in that the implant includes a first peripheral bone contact element that extends from the first body member to the second body member on a first lateral side of the implant.
[22]
24. Implant according to claim 23, characterized in that the implant includes a second bone contact element that extends from the first body member to the second body member on a second lateral side of the implant.
[23]
25. Implant, according to claim 24, characterized by the fact that the bone contact element
Petition 870190090779, of 12/09/2019, p. 19/21
Central 6/6 extends from the first peripheral bone contact element to the second peripheral bone contact element.
[24]
26. Implant, according to claim 25, characterized by the fact that the first peripheral bone contact element has a wavy plane geometry.
[25]
27. Implant, according to claim 21, characterized in that the implant includes an upper bone contact element that extends from the first body member to the second body member and in which the upper bone contact element is attached to the central bone contact element.
[26]
28. Implant, according to claim 27, characterized by the fact that the upper bone contact element has a generalized helical geometry.
[27]
29. Implant according to claim 28, characterized in that a portion of the upper bone contact element is aligned with a portion of the central bone contact element.

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同族专利:

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引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

CH672589A5|1987-07-09|1989-12-15|Sulzer Ag|

---

US6758849B1|1995-02-17|2004-07-06|Sdgi Holdings, Inc.|Interbody spinal fusion implants|

---

US6923810B1|1988-06-13|2005-08-02|Gary Karlin Michelson|Frusto-conical interbody spinal fusion implants|

---

US5609635A|1988-06-28|1997-03-11|Michelson; Gary K.|Lordotic interbody spinal fusion implants|

---

US4961740B1|1988-10-17|1997-01-14|Surgical Dynamics Inc|V-thread fusion cage and method of fusing a bone joint|

---

US5458638A|1989-07-06|1995-10-17|Spine-Tech, Inc.|Non-threaded spinal implant|

---

JPH04313005A|1991-04-08|1992-11-05|Mitsubishi Electric Corp|Film thickness measuring instrument|

---

JPH05328051A|1992-05-19|1993-12-10|Canon Inc|Image reader|

---

US5423816A|1993-07-29|1995-06-13|Lin; Chih I.|Intervertebral locking device|

---

CA2191089C|1994-05-23|2003-05-06|Douglas W. Kohrs|Intervertebral fusion implant|

---

DE4423257C2|1994-07-02|2001-07-12|Ulrich Heinrich|Implant to be inserted between the vertebral body of the spine as a placeholder|

---

DE19504867C1|1995-02-14|1996-02-29|Harms Juergen|Position retainer for spine|

---

US5607424A|1995-04-10|1997-03-04|Tropiano; Patrick|Domed cage|

---

US6039762A|1995-06-07|2000-03-21|Sdgi Holdings, Inc.|Reinforced bone graft substitutes|

---

US5709683A|1995-12-19|1998-01-20|Spine-Tech, Inc.|Interbody bone implant having conjoining stabilization features for bony fusion|

---

US5716416A|1996-09-10|1998-02-10|Lin; Chih-I|Artificial intervertebral disk and method for implanting the same|

---

US6585770B1|1997-06-02|2003-07-01|Sdgi Holdings, Inc.|Devices for supporting bony structures|

---

US5897556A|1997-06-02|1999-04-27|Sdgi Holdings, Inc.|Device for supporting weak bony structures|

---

US6149651A|1997-06-02|2000-11-21|Sdgi Holdings, Inc.|Device for supporting weak bony structures|

---

US6126689A|1998-06-15|2000-10-03|Expanding Concepts, L.L.C.|Collapsible and expandable interbody fusion device|

---

FR2774280B1|1998-01-30|2000-07-28|Dimso Sa|IMPLANT TO REPLACE A VERTEBRA|

---

DE19804765C2|1998-02-06|2000-09-28|Biedermann Motech Gmbh|Placeholder with adjustable axial length|

---

DE19818143A1|1998-04-23|1999-10-28|Medinorm Ag|Device for connecting vertebrae of the spine|

---

US6090143A|1998-09-21|2000-07-18|Meriwether; Michael W.|Box cage for intervertebral body fusion|

---

DE69924864T2|1998-10-30|2006-02-23|Michelson, Gary Karlin, Los Angeles|SELF-SPILLING, ROTATABLE, PLUG-IN SPONDYLOSE IMPLANT|

---

US6241770B1|1999-03-05|2001-06-05|Gary K. Michelson|Interbody spinal fusion implant having an anatomically conformed trailing end|

---

US6436141B2|2000-04-07|2002-08-20|Surgical Dynamics, Inc.|Apparatus for fusing adjacent bone structures|

---

EP1164979B1|1999-04-07|2005-12-21|Howmedica Osteonics Corp.|Low profile fusion cage and insertion set|

---

US6520996B1|1999-06-04|2003-02-18|Depuy Acromed, Incorporated|Orthopedic implant|

---

US7636752B2|1999-09-28|2009-12-22|Parlano, Inc.|System and method for managing information and collaborating|

---

US6206924B1|1999-10-20|2001-03-27|Interpore Cross Internat|Three-dimensional geometric bio-compatible porous engineered structure for use as a bone mass replacement or fusion augmentation device|

---

EP1221910B1|1999-10-20|2005-09-28|SDGI Holdings, Inc.|Impacted orthopedic bone support implant|

---

ES2269092T3|1999-12-15|2007-04-01|Zimmer Gmbh|INTERVERTEBRAL IMPLANT.|

---

KR200188511Y1|2000-01-06|2000-07-15|구자교|A supplement plug for spinal colulm|

---

US6808537B2|2000-07-07|2004-10-26|Gary Karlin Michelson|Expandable implant with interlocking walls|

---

EP1645248B8|2000-02-04|2010-06-16|Warsaw Orthopedic, Inc.|Expandable interbody spinal fusion implant having pivotally attached blocker|

---

US6709458B2|2000-02-04|2004-03-23|Gary Karlin Michelson|Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion|

---

JP4280445B2|2000-03-10|2009-06-17|ウォーソー・オーソペディック・インコーポレーテッド|Reinforced synthetic vertebral body fusion implant|

---

US6500205B1|2000-04-19|2002-12-31|Gary K. Michelson|Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion|

---

US6494883B1|2000-05-26|2002-12-17|Bret A. Ferree|Bone reinforcers|

---

GB2363115A|2000-06-10|2001-12-12|Secr Defence|Porous or polycrystalline silicon orthopaedic implants|

---

FR2812188B1|2000-07-31|2003-06-13|Spinevision Sa|RACHIS IMMOBILIZATION CAGE AND OSTEOSYNTHESIS, METHOD FOR MANUFACTURING THE CAGE AND DRILLING EQUIPMENT FOR THE LAYOUT OF THE CAGE|

---

US6582467B1|2000-10-31|2003-06-24|Vertelink Corporation|Expandable fusion cage|

---

US6989032B2|2001-07-16|2006-01-24|Spinecore, Inc.|Artificial intervertebral disc|

---

US20030078660A1|2001-02-15|2003-04-24|Dale Clifford|Orthopedic implant and method for orthopedic treatment|

---

US6827743B2|2001-02-28|2004-12-07|Sdgi Holdings, Inc.|Woven orthopedic implants|

---

US7128760B2|2001-03-27|2006-10-31|Warsaw Orthopedic, Inc.|Radially expanding interbody spinal fusion implants, instrumentation, and methods of insertion|

---

US6890355B2|2001-04-02|2005-05-10|Gary K. Michelson|Artificial contoured spinal fusion implants made of a material other than bone|

---

US20050177238A1|2001-05-01|2005-08-11|Khandkar Ashok C.|Radiolucent bone graft|

---

PT2055267E|2001-05-01|2013-07-15|Amedica Corp|Radiolucent bone graft|

---

US6974480B2|2001-05-03|2005-12-13|Synthes |Intervertebral implant for transforaminal posterior lumbar interbody fusion procedure|

---

US6863689B2|2001-07-16|2005-03-08|Spinecore, Inc.|Intervertebral spacer having a flexible wire mesh vertebral body contact element|

---

GB0119652D0|2001-08-11|2001-10-03|Stanmore Implants Worldwide|Surgical implant|

---

US20030083746A1|2001-10-31|2003-05-01|Kuslich Stephen D.|Vertebral spacer for spinal stabilization|

---

US7485134B2|2001-12-07|2009-02-03|Simonson Rush E|Vertebral implants adapted for posterior insertion|

---

US7527649B1|2002-02-15|2009-05-05|Nuvasive, Inc.|Intervertebral implant and related methods|

---

WO2003105673A2|2002-06-17|2003-12-24|Trimedyne, Inc.|Devices and methods for minimally invasive treatment of degenerated spinal discs|

---

US20060293753A1|2002-08-19|2006-12-28|Lanx, Llc|Corrective artificial disc|

---

JP4088495B2|2002-08-20|2008-05-21|昭和医科工業株式会社|Intervertebral cage|

---

JP4313005B2|2002-08-23|2009-08-12|タキロン株式会社|Implant material|

---

US6712852B1|2002-09-30|2004-03-30|Depuy Spine, Inc.|Laminoplasty cage|

---

CA2448592C|2002-11-08|2011-01-11|Howmedica Osteonics Corp.|Laser-produced porous surface|

---

EP1567075B1|2002-12-06|2013-11-27|Synthes GmbH|Device for osteosynthesis|

---

US7192447B2|2002-12-19|2007-03-20|Synthes |Intervertebral implant|

---

BRPI0317820B1|2003-02-06|2015-06-30|Synthes Gmbh|Intervertebral Implant|

---

US20040225361A1|2003-03-14|2004-11-11|Glenn Bradley J.|Intervertebral disk nuclear augmentation system|

---

DE10311477A1|2003-03-15|2004-09-23|Ulrich Gmbh & Co. Kg|Implant to be inserted between the vertebral body of the spine|

---

ES2331125T3|2003-03-24|2009-12-22|Synthes Gmbh|INTERVERTEBRAL DISK PROTECTION OR INTERVERTEBRAL PROTESIS.|

---

US20040193270A1|2003-03-31|2004-09-30|Depuyacromed, Inc.|Implantable bone graft|

---

US7563281B2|2003-04-03|2009-07-21|Warsaw Orthopedic, Inc.|Apparatus and method for supporting vertebral bodies|

---

ES2297133T3|2003-04-14|2008-05-01|Synthes Gmbh|INTERVERTEBRAL IMPLANT.|

---

US7141068B2|2003-07-01|2006-11-28|Thomas Ross|Spinal spacer assembly|

---

US7153325B2|2003-08-01|2006-12-26|Ultra-Kinetics, Inc.|Prosthetic intervertebral disc and methods for using the same|

---

US8062365B2|2003-08-04|2011-11-22|Warsaw Orthopedic, Inc.|Bone supporting devices with bio-absorbable end members|

---

GB0401362D0|2004-01-22|2004-02-25|Depuy Int Ltd|Vertebral fusion parts, devices and methods|

---

US20080306595A1|2004-03-26|2008-12-11|Pearsalls Limited|Porous Implant For Spinal Disc Nucleus Replacement|

---

US7465318B2|2004-04-15|2008-12-16|Soteira, Inc.|Cement-directing orthopedic implants|

---

US9232971B2|2004-04-15|2016-01-12|Globus Medical, Inc.|Cement-directing orthopedic implants|

---

DE102004021861A1|2004-05-04|2005-11-24|Biedermann Motech Gmbh|Implant for temporary or permanent replacement of vertebra or intervertebral disk, comprising solid central element and outer elements with openings|

---

US20060041262A1|2004-05-19|2006-02-23|Calvert Jay W|Interlaced wire for implants|

---

US7621952B2|2004-06-07|2009-11-24|Dfine, Inc.|Implants and methods for treating bone|

---

US7297162B2|2004-06-09|2007-11-20|Zimmer Spine, Inc.|Expandable helical cage|

---

US20050278027A1|2004-06-11|2005-12-15|Hyde Edward R Jr|Annulus fibrosus stent|

---

US20090112321A1|2005-08-04|2009-04-30|Kitchen Michael S|Spinal stabilization device and method|

---

DE102004041354A1|2004-08-25|2006-03-30|Buck, Alfred|Implant for surgical use in humans or vertebrates|

---

US20060058881A1|2004-09-16|2006-03-16|Trieu Hai H|Intervertebral disc nucleus implants and methods|

---

WO2006034436A2|2004-09-21|2006-03-30|Stout Medical Group, L.P.|Expandable support device and method of use|

---

US7452369B2|2004-10-18|2008-11-18|Barry Richard J|Spine microsurgery techniques, training aids and implants|

---

US7794500B2|2004-10-27|2010-09-14|Felix Brent A|Surgical implant|

---

US20060100706A1|2004-11-10|2006-05-11|Shadduck John H|Stent systems and methods for spine treatment|

---

US20060147332A1|2004-12-30|2006-07-06|Howmedica Osteonics Corp.|Laser-produced porous structure|

---

US8864831B2|2005-01-19|2014-10-21|K2M, Inc.|Fixation of elastomer to rigid structures|

---

US9402734B2|2010-07-30|2016-08-02|Igip, Llc|Spacer for spinal implant|

---

US8986383B2|2005-03-24|2015-03-24|Igip, Llc|End cap and connector for a spinal implant|

---

US9456907B1|2005-03-24|2016-10-04|Igip, Llc|Extendable spinal implant|

---

US8226718B2|2005-03-24|2012-07-24|Cardinal Spine, Llc|Spinal implant and method of using spinal implant|

---

US8361149B2|2005-03-24|2013-01-29|Cardinal Spine, Llc|Wedge-like spinal implant|

---

US7435261B1|2005-03-24|2008-10-14|Frank Castro|Spinal implant and method of using spinal implant|

---

US8246683B2|2005-03-24|2012-08-21|Cardinal Spine, Llc|Spinal implant|

---

US8673006B2|2005-03-24|2014-03-18|Igip, Llc|Spinal implant|

---

US8016887B1|2005-03-24|2011-09-13|Cardinal Spine, Llc|Spinal implant with overlay|

---

CA2604622A1|2005-04-15|2006-10-26|Musculoskeletal Transplant Foundation|Vertebral disc repair|

---

US7749270B2|2005-04-29|2010-07-06|Warsaw Orthopedic, Inc.|Expandable intervertebral implant and associated instrumentation|

---

US8262737B2|2005-05-06|2012-09-11|Titan Spine, Llc|Composite interbody spinal implant having openings of predetermined size and shape|

---

US20060271196A1|2005-05-26|2006-11-30|Saal Jeffrey A|Spinal disc annulus augmentation|

---

US8021426B2|2005-06-15|2011-09-20|Ouroboros Medical, Inc.|Mechanical apparatus and method for artificial disc replacement|

---

EP1903949A2|2005-07-14|2008-04-02|Stout Medical Group, L.P.|Expandable support device and method of use|

---

US20070027544A1|2005-07-28|2007-02-01|Altiva Corporation|Spinal cage implant|

---

JP4944111B2|2005-08-16|2012-05-30|ベンベニューメディカル，インコーポレイテッド|Spinal distractor|

---

US20070050032A1|2005-09-01|2007-03-01|Spinal Kinetics, Inc.|Prosthetic intervertebral discs|

---

US8882841B2|2005-09-16|2014-11-11|Us Spine, Inc.|Steerable interbody fusion cage|

---

CA2623448A1|2005-09-26|2007-03-29|Frank J. Schwab|Hybrid intervertebral spinal fusion implant|

---

CN103169533B|2005-09-27|2015-07-15|帕拉迪格脊骨有限责任公司|Interspinous vertebral stabilization devices|

---

EP1779814B1|2005-10-26|2009-03-18|BIEDERMANN MOTECH GmbH|Implant having a single piece swivel joint|

---

US7674294B2|2005-12-01|2010-03-09|Warsaw Orthopedic, Inc.|End device for a vertebral implant|

---

DE102005061932A1|2005-12-23|2007-07-05|Biedermann Motech Gmbh|Placeholder for implantation to the human vertebrae has three tubular bodies having different lengths and diameters that are inserted and connected to each other by pins so that they project over the edges of the next larger tubular body|

---

US20070198090A1|2006-02-03|2007-08-23|Abdou M S|Use of Carbon Nanotubes in the Manufacture of Orthopedic Implants|

---

WO2007130648A2|2006-05-05|2007-11-15|Ceramatec, Inc.|Fully or partially bioresorbable orthopedic implant|

---

US8092536B2|2006-05-24|2012-01-10|Disc Dynamics, Inc.|Retention structure for in situ formation of an intervertebral prosthesis|

---

ES2390567T3|2006-07-14|2012-11-14|Biedermann Technologies Gmbh & Co. Kg|Separator for insertion between two vertebrae|

---

US9278007B2|2006-09-26|2016-03-08|Spinal Kinetics, Inc.|Prosthetic intervertebral discs having cast end plates and methods for making and using them|

---

US9439948B2|2006-10-30|2016-09-13|The Regents Of The University Of Michigan|Degradable cage coated with mineral layers for spinal interbody fusion|

---

DE602006011762D1|2006-11-23|2010-03-04|Biedermann Motech Gmbh|Expandable intervertebral implant|

---

US8298286B2|2006-12-19|2012-10-30|Warsaw Orthopedic, Inc.|Non-linear vertebral mesh|

---

US20080177389A1|2006-12-21|2008-07-24|Rob Gene Parrish|Intervertebral disc spacer|

---

WO2008088869A1|2007-01-19|2008-07-24|Spinemedica Corporation|Methods and systems for forming implants with selectively exposed mesh for fixation|

---

EP1961433A1|2007-02-20|2008-08-27|National University of Ireland Galway|Porous substrates for implantation|

---

US11179243B2|2007-02-28|2021-11-23|Happe Spine Llc|Implantable devices|

---

JP5175867B2|2007-03-02|2013-04-03|エイテックステクノロジーズインコーポレイテッド|Textile medical device having tapered transition and method for manufacturing the same|

---

EP2152205A4|2007-04-18|2013-05-01|Nuvasive Inc|Textile-based surgical implant and related methods|

---

WO2008130654A1|2007-04-18|2008-10-30|Life Spine, Inc.|Spinal disc prostheses|

---

US20080312742A1|2007-06-12|2008-12-18|Dennis Lee Abernathie|Anterior Spinal Fusion and Fixation Cage with Integrated Plate and Method of Use|

---

BRPI0813946A2|2007-06-29|2015-01-06|Synthes Gmbh|FLEXIBLE CHAIN IMPLANT FOR INSERTING IN THE INTERNAL VOLUME FORMED IN A BONE.|

---

US7922767B2|2007-07-07|2011-04-12|Jmea Corporation|Disk fusion implant|

---

US20090062917A1|2007-08-27|2009-03-05|Foley Kevin T|Spinal interbody replacement devices|

---

WO2009051779A1|2007-10-17|2009-04-23|Kitchen Michael S|Spinal stabilization device and method|

---

US8182538B2|2007-10-31|2012-05-22|Depuy Spine, Inc.|Expandable fusion cage|

---

US20090149958A1|2007-11-01|2009-06-11|Ann Prewett|Structurally reinforced spinal nucleus implants|

---

DE102007056993A1|2007-11-27|2009-06-04|Kilian Kraus|Bone-contacting implants|

---

US8241363B2|2007-12-19|2012-08-14|Depuy Spine, Inc.|Expandable corpectomy spinal fusion cage|

---

US7799056B2|2007-12-31|2010-09-21|Warsaw Orthopedic, Inc.|Bone fusion device and methods|

---

JP5441922B2|2008-01-17|2014-03-12|ジンテスゲゼルシャフトミットベシュレンクテルハフツング|Inflatable intervertebral implant and related manufacturing method|

---

DE202008001079U1|2008-01-25|2008-03-27|Aesculap Ag & Co. Kg|Intervertebral implant|

---

US20090248162A1|2008-03-25|2009-10-01|Warsaw Orthopedic, Inc.|Microparticle delivery syringe and needle for placing suspensions and removing vehicle fluid|

---

FR2929502B1|2008-04-04|2011-04-08|Clariance|NUCLEIC IMPLANT.|

---

US8302259B2|2008-04-30|2012-11-06|Obe Ohnmacht & Baumgartner Gmbh & Co. Kg|Spring hinge for spectacles|

---

EP3064175A1|2015-03-03|2016-09-07|SMed - TA/TD LLC|Orthopaedic implant with porous structural member|

---

CA3029952A1|2018-01-24|2019-07-24|Smed-Ta/Td, Llc|Orthopaedic implant with porous structural member|

---

BRPI0917645A2|2008-09-02|2015-11-17|Synthes Gmbh|implant with spiral anchor.|

---

EP2172236A1|2008-10-03|2010-04-07|Koninklijke Philips Electronics N.V.|Breast pump system|

---

CA2743461C|2008-11-20|2017-07-11|Cartiheal Ltd.|Coral scaffold for cartilage or osteochondral repair|

---

CN102292054B|2008-12-17|2014-05-21|斯恩蒂斯有限公司|Full-metal dampening intervertebral implant|

---

ES2555487T3|2008-12-18|2016-01-04|4-Web, Inc.|Lattice lattice structure implant|

---

GB0903250D0|2009-02-26|2009-04-08|Depuy Int Ltd|Support structure implant for a bone cavity|

---

JP5455020B2|2009-06-08|2014-03-26|ナカシマメディカル株式会社|Intervertebral cage|

---

US20110015741A1|2009-07-16|2011-01-20|Warsaw Orthopedic, Inc.|Spinal implant configured to apply radiation treatment and method|

---

US9399086B2|2009-07-24|2016-07-26|Warsaw Orthopedic, Inc|Implantable medical devices|

---

CA2771386A1|2009-08-19|2011-04-07|Synthes Usa, Llc|Method and apparatus for augmenting bone|

---

US9615933B2|2009-09-15|2017-04-11|DePuy Synthes Products, Inc.|Expandable ring intervertebral fusion device|

---

US8361150B2|2009-09-23|2013-01-29|Zimmer Spine, Inc.|Composite implant|

---

WO2011048140A1|2009-10-20|2011-04-28|Tpl Technology Patents Licenses Kilian Kraus|Implant, method and tool for kyphoplasty|

---

US8303879B2|2010-02-01|2012-11-06|Sb Technologies, Llc|Composite interbody device and method of manufacture|

---

US20110245926A1|2010-03-31|2011-10-06|Kitchen Michael S|Intervertebral spacer and methods of use|

---

US20110301709A1|2010-06-03|2011-12-08|Kilian Kraus|Intervertebral implant|

---

US20110313532A1|2010-06-18|2011-12-22|Jessee Hunt|Bone implant interface system and method|

---

JP5328051B2|2010-07-14|2013-10-30|ナカシマメディカル株式会社|Intervertebral cage|

---

CN103068343B|2010-07-23|2016-08-03|普里韦勒普-施皮内股份公司|Surgery implant and relevant kit utility|

---

US20190298542A1|2010-07-23|2019-10-03|Privelop-Spine Ag|Surgical implant|

---

US20180338838A1|2016-02-03|2018-11-29|Globus Medical, Inc.|Intervertebral Spinal Implants, Associated Instruments, And Methods Thereof|

---

DE102010041959A1|2010-10-05|2012-04-05|Aces Gmbh|Medical implant|

---

US20120191188A1|2011-01-20|2012-07-26|Huang meng-feng|Spinal implant with bone engaging projections|

---

US20120191189A1|2011-01-20|2012-07-26|Huang meng-feng|Spinal implant with padded bone engaging projections|

---

US9623148B2|2011-01-28|2017-04-18|Spinesmith Partners, L.P.|Composite bone graft device|

---

US9271765B2|2011-02-24|2016-03-01|Spinal Elements, Inc.|Vertebral facet joint fusion implant and method for fusion|

---

US9326791B2|2011-03-23|2016-05-03|Aleeva Medical Inc.|Tissue repair with space-seeking spirals of filament|

---

AU2012236149B2|2011-03-30|2016-05-19|Trinity Orthopedics, Llc|Articulating interbody cage and methods thereof|

---

US9039766B1|2011-06-30|2015-05-26|Mx Orthopedics, Corp.|Wave spring for a spinal implant|

---

CN103826573B|2011-07-05|2017-07-11|扩张整形外科公司|Bone structure utensil|

---

US9186252B2|2011-07-26|2015-11-17|Rita Leibinger GmbH & Co. KG|Tibia implant for tightening the patella tendons|

---

US20130030529A1|2011-07-29|2013-01-31|Jessee Hunt|Implant interface system and method|

---

US8454700B2|2011-10-04|2013-06-04|Zimmer Spine, Inc.|Interbody vertebral spacer|

---

CA2854021C|2011-11-03|2020-05-05|4-Web, Inc.|Method of length preservation during bone repair|

---

US20130184826A1|2011-12-22|2013-07-18|Basix Spine Llc|Bioabsorbable enclosures|

---

AU2013216947A1|2012-02-08|2014-08-28|4-Web, Inc.|Prosthetic implant for ball and socket joints and method of use|

---

US9155819B2|2012-02-09|2015-10-13|Mx Orthopedics, Corp.|Dynamic porous coating for orthopedic implant|

---

JP5684177B2|2012-03-19|2015-03-11|シンセス ゲゼルシャフト ミット ベシュレンクテル ハフツングＳｙｎｔｈｅｓ Ｇｍｂｈ|Porous implant|

---

US8771368B2|2012-04-24|2014-07-08|William F. McKay|Interspinous bone implant device|

---

US9839553B2|2012-06-20|2017-12-12|Bio Cybernetics International, Inc.|Automated orthotic device with treatment regimen and method for using the same|

---

US10561456B2|2014-07-24|2020-02-18|KYOCERA Medical Technologies, Inc.|Bone screw incorporating a porous surface formed by an additive manufacturing process|

---

US10154913B2|2012-06-21|2018-12-18|Renovis Surgical Technologies, Inc.|Surgical implant devices incorporating porous surfaces and a locking plate|

---

US10765530B2|2012-06-21|2020-09-08|Renovis Surgical Technologies, Inc.|Surgical implant devices incorporating porous surfaces|

---

EP2877127B1|2012-07-26|2019-08-21|Synthes GmbH|Expandable implant|

---

US9226831B2|2012-08-27|2016-01-05|Globus Medical, Inc.|Intervertebral implant|

---

US9271845B2|2012-09-25|2016-03-01|4Web|Programmable implants and methods of using programmable implants to repair bone structures|

---

US8475533B1|2012-09-27|2013-07-02|Igip, Llc|System and stabilizer for spinal implant and methods of assisting stabilization of spinal implant|

---

WO2014048494A1|2012-09-28|2014-04-03|Telefonaktiebolaget L M Ericsson |Interference- protected control message transmission in a mobile communications network|

---

US9186257B2|2012-10-11|2015-11-17|Rhausler, Inc.|Bone plate and fusion cage interface|

---

US20170020685A1|2012-10-11|2017-01-26|Rhausler, Inc.|Fusion cage implant with lattice structure and grooves|

---

ITPI20120106A1|2012-10-19|2014-04-20|Giancarlo Guizzardi|DEVICE AND SYSTEM FOR VERTEBRAL ARTHRODES|

---

US9622880B2|2012-10-23|2017-04-18|Spinesmith Partners, L.P.|Mesenchymal cell-based soft fusion as a biological intervertebral disc replacement|

---

US9265609B2|2013-01-08|2016-02-23|Warsaw Orthopedic, Inc.|Osteograft implant|

---

US8900312B2|2013-03-12|2014-12-02|Spine Wave, Inc.|Expandable interbody fusion device with graft chambers|

---

US20140277569A1|2013-03-13|2014-09-18|Warsaw Orthopedic, Inc.|Hybrid osteoinductive bone graft|

---

US9358120B2|2013-03-14|2016-06-07|DePuy Synthes Products, Inc.|Expandable coil spinal implant|

---

CA2911880C|2013-03-15|2022-02-08|4-Web, Inc.|Traumatic bone fracture repair systems and methods|

---

US20140288650A1|2013-03-15|2014-09-25|4Web, Inc.|Motion preservation implant and methods|

---

AU2013221955B2|2013-04-12|2017-06-22|Mosci Corp.|Bioactive glass scaffolds, and method of making|

---

DE202014003441U1|2013-08-14|2014-11-18|Joimax Gmbh|Intervertebral Cup|

---

US9839528B2|2014-02-07|2017-12-12|Globus Medical, Inc.|Variable lordosis spacer and related methods of use|

---

US9662224B2|2014-02-07|2017-05-30|Globus Medical, Inc.|Variable lordosis spacer and related methods of use|

---

EP3134035A1|2014-04-25|2017-03-01|Neo Medical SA|Spine cage|

---

US9662226B2|2014-07-28|2017-05-30|Warsaw Orthopedic, Inc.|Spinal implant system and method|

---

US9649200B2|2014-07-28|2017-05-16|Wasaw Orthopedic, Inc.|Spinal implant system and method|

---

US9782270B2|2014-08-08|2017-10-10|Warsaw Orthopedic, Inc.|Spinal implant system and method|

---

JP2018504146A|2014-08-29|2018-02-15|ニューサウス・イノベーションズ・ピーティーワイ・リミテッド|Fixed device|

---

ES2826600T3|2014-09-18|2021-05-18|Si Bone Inc|Matrix implant|

---

US10898333B2|2014-10-16|2021-01-26|Ht Medical Llc|Additive manufactured titanium bone device|

---

KR101524532B1|2014-12-01|2015-06-01|조대진|Intervertebral cage for spinal implant|

---

US20160184099A1|2014-12-29|2016-06-30|Yechiel Gotfried|Orthopedic implants|

---

AU2016200179B2|2015-01-14|2020-09-17|Stryker European Operations Holdings Llc|Spinal implant with porous and solid surfaces|

---

US9060876B1|2015-01-20|2015-06-23|Ouroboros Medical, Inc.|Stabilized intervertebral scaffolding systems|

---

US9907670B2|2015-01-21|2018-03-06|Warsaw Orthopedic, Inc.|Unitarily formed expandable spinal implant and method of manufacturing and implanting same|

---

US20160213405A1|2015-01-27|2016-07-28|K2M, Inc.|Vertebral plate systems and methods of use|

---

US10413427B2|2015-03-19|2019-09-17|Warsaw Orthopedic, Inc.|Spinal implant system and method|

---

US10449055B2|2015-04-23|2019-10-22|Disc Fix L.L.C.|Systems and methods for treatment of intervertebral disc derangements|

---

US10449051B2|2015-04-29|2019-10-22|Institute for Musculoskeletal Science and Education, Ltd.|Implant with curved bone contacting elements|

---

EP3760166A1|2015-04-29|2021-01-06|Institute For Musculoskeletal Science And Education, Ltd.|Coiled implants and systems|

---

US10709570B2|2015-04-29|2020-07-14|Institute for Musculoskeletal Science and Education, Ltd.|Implant with a diagonal insertion axis|

---

US10492921B2|2015-04-29|2019-12-03|Institute for Musculoskeletal Science and Education, Ltd.|Implant with arched bone contacting elements|

---

FR3036030B1|2015-05-11|2021-01-29|Lokou David Fischer|IMPLANT FOR FIXING BONE ELEMENTS|

---

FR3036102B1|2015-05-12|2017-05-26|Airbus Defence & Space Sas|METHOD AND SYSTEM FOR DETECTING FAILURE OF A PROPULSION ARM OF A SPATIAL VEHICLE, SUCH AS A SATELLITE|

---

CA2930123A1|2015-05-18|2016-11-18|Stryker European Holdings I, Llc|Partially resorbable implants and methods|

---

DE102015110202B3|2015-06-25|2016-06-09|Heraeus Medical Gmbh|Kit for constructing a cage for spinal fusion and method therefor and corresponding cage and its use|

---

FR3038831B1|2015-07-16|2017-07-21|Spineart Sa|INTERVERTEBRAL CAGE FOR ARTHRODESIS|

---

GB201609448D0|2015-09-10|2016-07-13|Obl S A|Medical device|

---

WO2017046667A1|2015-09-14|2017-03-23|Uri Arnin|Facet distraction and fusion prosthesis|

---

US20170258606A1|2015-10-21|2017-09-14|Thomas Afzal|3d printed osteogenesis scaffold|

---

EP3377255A1|2015-11-20|2018-09-26|Titan Spine, Inc.|Processes for additively manufacturing orthopedic implants|

---

US10166116B2|2015-12-02|2019-01-01|Brian Patrick Janowski|Helical lock spacer, instruments and methods|

---

EP3386444B1|2015-12-07|2020-11-18|Nexus Spine, L.L.C.|Porous interbody spacer|

---

TWI587847B|2015-12-07|2017-06-21|財團法人工業技術研究院|Implant device for osseous integration|

---

BR112018012191A2|2015-12-16|2018-11-27|Nuvasive, Inc.|porous spinal fusion implant|

---

DE102015226063A1|2015-12-18|2017-06-22|Aesculap Ag|Medical product and medical kit for use in the treatment, in particular for use in filling and / or closure, a bone cavity|

---

EP3407837B1|2016-01-28|2021-07-07|DePuy Synthes Products, Inc.|Helical bone graft containment cage|

---

EP3603580A1|2018-08-02|2020-02-05|Globus Medical, Inc.|Intervertebral spinal implants, associated instruments|

---

FR3050927B1|2016-05-03|2022-01-07|Ldr Medical|VERTEBRAL IMPLANT AND INSERT FOR VERTEBRAL IMPLANT|

---

US10660764B2|2016-06-14|2020-05-26|The Trustees Of The Stevens Institute Of Technology|Load sustaining bone scaffolds for spinal fusion utilizing hyperbolic struts and translational strength gradients|

---

JP6700135B2|2016-07-25|2020-05-27|日本特殊陶業株式会社|Vertebral body spacer|

---

US10265189B2|2016-09-13|2019-04-23|Warsaw Orthopedic, Inc.|Interbody spinal fusion device|

---

US10278834B2|2016-09-14|2019-05-07|Globus Medical, Inc.|Center lordotic mesh cage|

---

EP3494931A1|2017-12-08|2019-06-12|Globus Medical, Inc.|Center lordotic mesh cage|

---

US10278833B2|2016-09-14|2019-05-07|Globus Medical, Inc.|Center lordotic mesh cage|

---

US20190254840A1|2016-09-16|2019-08-22|Mirus Llc|Interbody fusion devices and related methods of manufacture|

---

US10716678B2|2016-09-20|2020-07-21|DePuy Synthes Products, Inc.|Intervertebral implant|

---

US11033394B2|2016-10-25|2021-06-15|Institute for Musculoskeletal Science and Education, Ltd.|Implant with multi-layer bone interfacing lattice|

---

US10478312B2|2016-10-25|2019-11-19|Institute for Musculoskeletal Science and Education, Ltd.|Implant with protected fusion zones|

---

WO2018112050A2|2016-12-13|2018-06-21|Aurora Spine, Inc.|Body density scan result-matched orthopedic implants and methods of use|

---

US11135065B2|2017-03-10|2021-10-05|Life Spine, Inc.|3-D printed orthopedic implants|

---

US10667924B2|2017-03-13|2020-06-02|Institute for Musculoskeletal Science and Education, Ltd.|Corpectomy implant|

---

US10357377B2|2017-03-13|2019-07-23|Institute for Musculoskeletal Science and Education, Ltd.|Implant with bone contacting elements having helical and undulating planar geometries|

---

US10512549B2|2017-03-13|2019-12-24|Institute for Musculoskeletal Science and Education, Ltd.|Implant with structural members arranged around a ring|

---

US10213317B2|2017-03-13|2019-02-26|Institute for Musculoskeletal Science and Education|Implant with supported helical members|

---

GB2561293A|2017-03-14|2018-10-10|Alphatec Spine Inc|Intervertebral Cage with porosity gradient|

---

US10368997B2|2017-04-01|2019-08-06|HD LifeSciences LLC|Three-dimensional lattice structures for implants|

---

US11109983B2|2018-03-21|2021-09-07|Life Spine, Inc.|Steerable TLIF spine implant, installer, and method of installation|

---

WO2018195260A1|2017-04-19|2018-10-25|Life Spine Inc. |Stand-alone alif spine implants|

---

US20200138595A1|2017-04-19|2020-05-07|Life Spine, Inc.|Implant with bone screw retention|

---

EP3633079A4|2017-05-22|2021-03-17|Sumitomo Electric Industries, Ltd.|Composite metal porous body and method for producing composite metal porous body|

---

US10624760B2|2017-05-22|2020-04-21|Warsaw Orthopedic, Inc.|Spinal implant system and method|

---

KR20200010200A|2017-05-22|2020-01-30|스미토모덴키고교가부시키가이샤|Metal porous body and manufacturing method of the metal porous body|

---

KR101806140B1|2017-06-29|2017-12-15|주식회사 멘티스로지텍|Spinal implant with unit structure printed 3d printer|

---

US20190015209A1|2017-07-17|2019-01-17|Warsaw Orthopedic, Inc.|Bone implant having a mesh|

---

JPWO2019026540A1|2017-08-01|2020-06-11|学校法人中部大学|Bioactive three-dimensional structure and method for producing the same|

---

EP3672649A1|2017-08-25|2020-07-01|CeramTec GmbH|Ceramic part having at least one ceramic foam for medical applications|

---

JP2019041886A|2017-08-30|2019-03-22|日本特殊陶業株式会社|Vertebral spacer|

---

US11147682B2|2017-09-08|2021-10-19|Pioneer Surgical Technology, Inc.|Intervertebral implants, instruments, and methods|

---

DE102017008592A1|2017-09-13|2019-03-14|Joimax Gmbh|Intervertebral implant|

---

EP3459502A1|2017-09-20|2019-03-27|Stryker European Holdings I, LLC|Spinal implants|

---

US20190133769A1|2017-11-06|2019-05-09|Kevin D. Tetsworth|Truss implant with rounded corners|

---

US10940015B2|2017-11-21|2021-03-09|Institute for Musculoskeletal Science and Education, Ltd.|Implant with improved flow characteristics|

---

US10744001B2|2017-11-21|2020-08-18|Institute for Musculoskeletal Science and Education, Ltd.|Implant with improved bone contact|

---

US11039933B2|2017-12-15|2021-06-22|Innovasis, Inc.|Interbody spinal fusion implant with support struts|

---

EP3737339A1|2018-01-11|2020-11-18|K2M, Inc.|Implants and instruments with flexible features|

---

US10695192B2|2018-01-31|2020-06-30|Institute for Musculoskeletal Science and Education, Ltd.|Implant with internal support members|

---

US10993814B2|2018-02-27|2021-05-04|Life Spine, Inc.|Height adjustable spine implant|

---

EP3761915A4|2018-03-08|2021-12-22|Nexus Spine, L.L.C.|Stand-alone interbody fusion|

---

JP2019180797A|2018-04-09|2019-10-24|日本特殊陶業株式会社|Vertebral body spacer|

---

US20190314169A1|2018-04-16|2019-10-17|Amit Patel|Coated and layered vertebral disc arthrodesis prothesis|

---

US10682238B2|2018-05-08|2020-06-16|Globus Medical, Inc.|Intervertebral spinal implant|

---

US10744003B2|2018-05-08|2020-08-18|Globus Medical, Inc.|Intervertebral spinal implant|

---

US10524927B2|2018-05-08|2020-01-07|Globus Medical, Inc.|Intervertebral spinal implant|

---

JP2019201688A|2018-05-21|2019-11-28|学校法人早稲田大学|Biological implantation material comprising promotion property of bone growth and production method thereof|

---

US10722378B2|2018-08-21|2020-07-28|Warsaw Orthopedic, Inc.|Surgical implant including a body portion and at least one attached tier|

---

TWM573218U|2018-10-15|2019-01-21|謝瑞洋|Support for implanting in or between bones of an individual and implant assembly and implant system therewith|

---

CA3063846A1|2018-12-05|2020-06-05|Smed-Ta/Td, Llc|Adjusted stiffness orthopaedic implants and method of manufacture|

---

US11185423B2|2019-01-09|2021-11-30|Osseus Fusion Systems|Highly radiographically opaque metal based interbody|

---

US11039931B2|2019-02-01|2021-06-22|Globus Medical, Inc.|Intervertebral spinal implant|

---

US20200276019A1|2019-02-07|2020-09-03|PrinterPrezz, Inc.|Three dimensionally printed and nanocoated medical implants|

---

US20200281727A1|2019-02-12|2020-09-10|PrinterPrezz, Inc.|Selective nano surface modulation of medical devices|

---

US20200297505A1|2019-03-19|2020-09-24|Amplify, Inc.|Internal Bone Fixation Device|

---

JP2021016498A|2019-07-18|2021-02-15|Ｔｏｗａ株式会社|Implant for bone treatment, manufacturing method of implant for bone treatment, and manufacturing device of implant for bone treatment|

---

US10772732B1|2020-01-08|2020-09-15|Restor3D, Inc.|Sheet based triply periodic minimal surface implants for promoting osseointegration and methods for producing same|US11147688B2|2013-10-15|2021-10-19|Si-Bone Inc.|Implant placement|

---

ES2826600T3|2014-09-18|2021-05-18|Si Bone Inc|Matrix implant|

---

EP3760166A1|2015-04-29|2021-01-06|Institute For Musculoskeletal Science And Education, Ltd.|Coiled implants and systems|

---

US10449051B2|2015-04-29|2019-10-22|Institute for Musculoskeletal Science and Education, Ltd.|Implant with curved bone contacting elements|

---

US10492921B2|2015-04-29|2019-12-03|Institute for Musculoskeletal Science and Education, Ltd.|Implant with arched bone contacting elements|

---

US20170258606A1|2015-10-21|2017-09-14|Thomas Afzal|3d printed osteogenesis scaffold|

---

US11033394B2|2016-10-25|2021-06-15|Institute for Musculoskeletal Science and Education, Ltd.|Implant with multi-layer bone interfacing lattice|

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US10512549B2|2017-03-13|2019-12-24|Institute for Musculoskeletal Science and Education, Ltd.|Implant with structural members arranged around a ring|

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US10357377B2|2017-03-13|2019-07-23|Institute for Musculoskeletal Science and Education, Ltd.|Implant with bone contacting elements having helical and undulating planar geometries|

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US11116519B2|2017-09-26|2021-09-14|Si-Bone Inc.|Systems and methods for decorticating the sacroiliac joint|

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US10940015B2|2017-11-21|2021-03-09|Institute for Musculoskeletal Science and Education, Ltd.|Implant with improved flow characteristics|

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US10744001B2|2017-11-21|2020-08-18|Institute for Musculoskeletal Science and Education, Ltd.|Implant with improved bone contact|

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US10695192B2|2018-01-31|2020-06-30|Institute for Musculoskeletal Science and Education, Ltd.|Implant with internal support members|

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KR101978440B1|2018-11-28|2019-05-14|고등기술연구원연구조합|Scaffold for bone reconstruction|

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DE102018130205A1|2018-11-28|2020-05-28|Aesculap Ag|Medical chain network|

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EP3923829A1|2019-02-14|2021-12-22|SI-Bone, Inc.|Implants for spinal fixation and or fusion|

法律状态:
2021-10-19| B350| Update of information on the portal [chapter 15.35 patent gazette]|

优先权:

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申请号 | 申请日 | 专利标题

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US15/457,515|US10357377B2|2017-03-13|2017-03-13|Implant with bone contacting elements having helical and undulating planar geometries|

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PCT/US2018/022021|WO2018169871A1|2017-03-13|2018-03-12|Implant with bone contacting elements having helical and undulating planar geometries|

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